Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE_1-relB/RelE(toxin)
Location 4129529..4130004 Replicon chromosome
Accession NZ_CP074412
Organism Pseudomonas viridiflava strain U625

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag KHW14_RS17840 Protein ID WP_096766753.1
Coordinates 4129529..4129810 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KHW14_RS17845 Protein ID WP_122522127.1
Coordinates 4129810..4130004 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW14_RS17815 (KHW14_17815) 4124734..4127061 + 2328 WP_122430975.1 ATP-binding protein -
KHW14_RS17820 (KHW14_17820) 4127058..4127522 + 465 WP_004881182.1 response regulator -
KHW14_RS17825 (KHW14_17825) 4127531..4127962 - 432 WP_029242988.1 universal stress protein -
KHW14_RS17830 (KHW14_17830) 4128108..4129118 - 1011 WP_122563754.1 tRNA dihydrouridine(20/20a) synthase DusA -
KHW14_RS17835 (KHW14_17835) 4129224..4129352 + 129 Protein_3523 site-specific integrase -
KHW14_RS17840 (KHW14_17840) 4129529..4129810 - 282 WP_096766753.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHW14_RS17845 (KHW14_17845) 4129810..4130004 - 195 WP_122522127.1 stability determinant Antitoxin
KHW14_RS17850 (KHW14_17850) 4130241..4130651 - 411 WP_043306709.1 S24 family peptidase -
KHW14_RS17855 (KHW14_17855) 4130749..4131990 - 1242 WP_122563753.1 M20/M25/M40 family metallo-hydrolase -
KHW14_RS17860 (KHW14_17860) 4132257..4134428 + 2172 WP_122407422.1 TonB-dependent siderophore receptor -
KHW14_RS17865 (KHW14_17865) 4134503..4134982 - 480 WP_043306668.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10473.22 Da        Isoelectric Point: 9.8796

>T202062 WP_096766753.1 NZ_CP074412:c4129810-4129529 [Pseudomonas viridiflava]
MLPIVWLQAAVNDLSSIILYIANENPSAARRLKSRLQAAPLPLAEHPYLFPLGRVSGTRELVAHPNYIIVYRIASDRVEI
VNVLHSRQTYPLT

Download         Length: 282 bp

>T202062 NZ_CP099304:4536911-4537129 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7069.82 Da        Isoelectric Point: 4.1947

>AT202062 WP_122522127.1 NZ_CP074412:c4130004-4129810 [Pseudomonas viridiflava]
MSTTLSPIVSEFDTQEQADSYDLWFRAKVEASLAEPGRAVPHDEVMARMDAIIEAAEARQRSGS

Download         Length: 195 bp

>AT202062 NZ_CP099304:4536510-4536884 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCGACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGATGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCTGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References