Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4193799..4194422 Replicon chromosome
Accession NZ_CP074411
Organism Pseudomonas syringae strain Susan762

Toxin (Protein)


Gene name hicA Uniprot ID A0A3M3C685
Locus tag KHW13_RS17950 Protein ID WP_003314536.1
Coordinates 4194240..4194422 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3M3C5W4
Locus tag KHW13_RS17945 Protein ID WP_010421644.1
Coordinates 4193799..4194203 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW13_RS17930 (KHW13_17930) 4189565..4190233 + 669 WP_024683928.1 ABC transporter ATP-binding protein -
KHW13_RS17935 (KHW13_17935) 4190233..4192713 + 2481 WP_213567506.1 ABC transporter permease -
KHW13_RS17940 (KHW13_17940) 4192703..4193782 + 1080 WP_213567507.1 lipocalin-like domain-containing protein -
KHW13_RS17945 (KHW13_17945) 4193799..4194203 - 405 WP_010421644.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KHW13_RS17950 (KHW13_17950) 4194240..4194422 - 183 WP_003314536.1 type II toxin-antitoxin system HicA family toxin Toxin
KHW13_RS17955 (KHW13_17955) 4194707..4196479 + 1773 WP_213567508.1 N-acetylglutaminylglutamine amidotransferase -
KHW13_RS17960 (KHW13_17960) 4196483..4198231 + 1749 WP_024683931.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6763.96 Da        Isoelectric Point: 10.6643

>T202059 WP_003314536.1 NZ_CP074411:c4194422-4194240 [Pseudomonas syringae]
VQSRQLIKELEADGWVLDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

>T202059 NZ_CP099304:873759-874169 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14568.66 Da        Isoelectric Point: 5.5960

>AT202059 WP_010421644.1 NZ_CP074411:c4194203-4193799 [Pseudomonas syringae]
MKYPMCIEWGNETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAASGRTIPKAGNVAEHARNPDFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT202059 NZ_CP099304:873512-873778 [Klebsiella michiganensis]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3C685

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3C5W4

References