Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1824720..1825233 Replicon chromosome
Accession NZ_CP074411
Organism Pseudomonas syringae strain Susan762

Toxin (Protein)


Gene name relE Uniprot ID A0A0P9GC66
Locus tag KHW13_RS08080 Protein ID WP_003423365.1
Coordinates 1824720..1825004 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0P9IXK3
Locus tag KHW13_RS08085 Protein ID WP_004418474.1
Coordinates 1824994..1825233 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW13_RS08065 (KHW13_08065) 1820862..1822790 + 1929 WP_213568173.1 methyl-accepting chemotaxis protein -
KHW13_RS08070 (KHW13_08070) 1822824..1823756 - 933 WP_122220097.1 DMT family transporter -
KHW13_RS08075 (KHW13_08075) 1823831..1824685 + 855 WP_122220096.1 LysR family transcriptional regulator -
KHW13_RS08080 (KHW13_08080) 1824720..1825004 - 285 WP_003423365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHW13_RS08085 (KHW13_08085) 1824994..1825233 - 240 WP_004418474.1 CopG family ribbon-helix-helix protein Antitoxin
KHW13_RS08090 (KHW13_08090) 1825392..1826408 - 1017 WP_003423368.1 1-aminocyclopropane-1-carboxylate deaminase -
KHW13_RS08095 (KHW13_08095) 1826595..1827101 + 507 WP_003315203.1 Lrp/AsnC family transcriptional regulator -
KHW13_RS08100 (KHW13_08100) 1827248..1828156 + 909 WP_024662002.1 DUF808 domain-containing protein -
KHW13_RS08105 (KHW13_08105) 1828336..1829121 - 786 WP_074908245.1 outer membrane protein OmpK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10632.34 Da        Isoelectric Point: 10.4249

>T202058 WP_003423365.1 NZ_CP074411:c1825004-1824720 [Pseudomonas syringae]
MQVEWLKTALKNLDEEAAYIALDNPAAAAAFVKAIQSSVTQLASFPAMGREGRIAGTREWPLPDLPYLIPYRIRSGRLQV
LRIFHTRRQSPPVW

Download         Length: 285 bp

>T202058 NZ_CP099304:c58648-58340 [Klebsiella michiganensis]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8670.76 Da        Isoelectric Point: 4.4217

>AT202058 WP_004418474.1 NZ_CP074411:c1825233-1824994 [Pseudomonas syringae]
MSTMSLRLPDEMADTLAHLAKATGRSKSFLALDALREYLTREAWQIAEIQRAIEEADAGEFASPDDVKAVMDKWSGNAG

Download         Length: 240 bp

>AT202058 NZ_CP099304:c58887-58651 [Klebsiella michiganensis]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P9GC66

Antitoxin

Source ID Structure
AlphaFold DB A0A0P9IXK3

References