Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1977959..1978472 Replicon chromosome
Accession NZ_CP074410
Organism Pseudomonas syringae strain U643

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KHW15_RS08860 Protein ID WP_103363385.1
Coordinates 1977959..1978243 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3M4E5F0
Locus tag KHW15_RS08865 Protein ID WP_024648170.1
Coordinates 1978233..1978472 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW15_RS08845 (KHW15_08845) 1974101..1976029 + 1929 WP_016567635.1 methyl-accepting chemotaxis protein -
KHW15_RS08850 (KHW15_08850) 1976063..1976995 - 933 WP_032660393.1 DMT family transporter -
KHW15_RS08855 (KHW15_08855) 1977070..1977924 + 855 WP_003423353.1 LysR family transcriptional regulator -
KHW15_RS08860 (KHW15_08860) 1977959..1978243 - 285 WP_103363385.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHW15_RS08865 (KHW15_08865) 1978233..1978472 - 240 WP_024648170.1 CopG family ribbon-helix-helix protein Antitoxin
KHW15_RS08870 (KHW15_08870) 1978632..1979648 - 1017 WP_213569413.1 1-aminocyclopropane-1-carboxylate deaminase -
KHW15_RS08875 (KHW15_08875) 1979835..1980341 + 507 WP_003315203.1 Lrp/AsnC family transcriptional regulator -
KHW15_RS08880 (KHW15_08880) 1980489..1981397 + 909 WP_032660395.1 DUF808 domain-containing protein -
KHW15_RS08885 (KHW15_08885) 1981574..1982359 - 786 WP_003396313.1 outer membrane protein OmpK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10659.37 Da        Isoelectric Point: 10.4249

>T202056 WP_103363385.1 NZ_CP074410:c1978243-1977959 [Pseudomonas syringae]
MQVEWLKTALKNLDEEAAYIALDNPAAAAAFVKAIQSNVTQLASFPAMGREGRIAGTREWPLPDLPYLIPYRIRSGRLQV
LRIFHTRRQSPPVW

Download         Length: 285 bp

>T202056 NZ_CP099303:c4471947-4471588 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACTTGCTTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCAGGGGTTC
TGGAGGTCGTTGAGGATTACCACGGTAGCGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAATCCGTTTCCGGAAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8715.80 Da        Isoelectric Point: 4.4354

>AT202056 WP_024648170.1 NZ_CP074410:c1978472-1978233 [Pseudomonas syringae]
MSTMSLRLPDEMADTLAHLAKATGRSKSFLALDALREYLTREAWQIAEIQRAIEEADAGEFASQEDVKAVMDKWSGNAG

Download         Length: 240 bp

>AT202056 NZ_CP099303:c4471598-4471281 [Citrobacter freundii]
ATGTCACATGAAGTGGAAGCTAGTAGCGGTAATGTTTACGCCGATTTAGGCGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAACTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCTGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGCTACGTGGTCAGTTTCGTGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGACTGGGCCGTGATGTAGAGATTGTTGTCGGGGAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3M4E5F0

References