202054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4427447..4427909 Replicon chromosome
Accession NZ_CP074409
Organism Pseudomonas syringae strain KF529

Toxin (Protein)


Gene name relE Uniprot ID A0A0P9XJI4
Locus tag KHW12_RS19090 Protein ID WP_003393317.1
Coordinates 4427628..4427909 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3M2UJ05
Locus tag KHW12_RS19085 Protein ID WP_003393315.1
Coordinates 4427447..4427638 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHW12_RS19065 (KHW12_19060) 4422523..4423785 - 1263 WP_096113080.1 MFS transporter -
KHW12_RS19070 (KHW12_19065) 4423891..4424784 + 894 WP_024650586.1 LysR family transcriptional regulator -
KHW12_RS19075 (KHW12_19070) 4424801..4425913 - 1113 WP_213629621.1 hypothetical protein -
KHW12_RS19080 (KHW12_19075) 4426074..4427384 + 1311 WP_046265623.1 mechanosensitive ion channel family protein -
KHW12_RS19085 (KHW12_19080) 4427447..4427638 + 192 WP_003393315.1 hypothetical protein Antitoxin
KHW12_RS19090 (KHW12_19085) 4427628..4427909 + 282 WP_003393317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHW12_RS19095 (KHW12_19090) 4428099..4430306 + 2208 WP_249732437.1 alpha/beta hydrolase domain-containing protein -
KHW12_RS19100 (KHW12_19095) 4430345..4430596 + 252 WP_024662863.1 hypothetical protein -
KHW12_RS19105 (KHW12_19100) 4431171..4432292 + 1122 WP_213629623.1 AAA family ATPase -
KHW12_RS19110 (KHW12_19105) 4432289..4432735 + 447 WP_210077280.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10563.26 Da        Isoelectric Point: 9.7428

>T202054 WP_003393317.1 NZ_CP074409:4427628-4427909 [Pseudomonas syringae]
MLVEWRPAARMNLKQILSYIADRNIRAASELGMAIEVATSALPQHPYLYRHGRVHGTREIVVHPNYLVVYKVTDRIEVLA
VLHARQAYPTDAG

Download         Length: 282 bp

>T202054 NZ_CP099303:c4154392-4154072 [Citrobacter freundii]
ATGCACATTTCAACTGTACCGGCCAAGGTATCGGTTTCGTCACGTCTGTCGCCCGTGCAGGTCTGGCAGCAACTTTTAAC
GTATCTGCTGAATCACCATTACGGCCTGACGCTTAACGACACGCCATTCCATGACGACACGGCCATTCAGGAGCATATTG
AAGCTGGTATTGTAATTGCTGATGCAGTGAATTTCCTGGTGGAACGCTATGAACTGGTACGCACTGACCGTAAGGGATTC
ACTTGGCAAGATCAGACACCATTCCTGACCGCCACCGATATTCTCAGAGCCAGACGAGCTACCGGATTAATAAATACTTG
A

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6977.73 Da        Isoelectric Point: 4.2322

>AT202054 WP_003393315.1 NZ_CP074409:4427447-4427638 [Pseudomonas syringae]
MSARISPIVSEFETEEQAASYDKWFRAQVQASINDPAPNISHDQVMAEMRALLESKQPPSDAG

Download         Length: 192 bp

>AT202054 NZ_CP099303:c4154752-4154429 [Citrobacter freundii]
ATGCCATTCACACTACCCCATGAATGGGGGCTACAAAGCGATATCACCCCACGATTTGGCGCAAGATTAGTTCAGGAAGG
CACCCGGCTGCATTACCTGGCTGACAGGGCTGGTTTGACGGGGGAAATTACCTCGAAGCAACTGCAGAAACTGGATCAAA
CTTTCCCGCTGTTTATCAGTAAATTGGAAGCAATGCTGTGCTCCGGTGAGCTAAATTCACAGCAGCAACATCAGGTGACC
ATTCAACTTGCGAGTCTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCAACCCC
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P9XJI4

Antitoxin

Source ID Structure
AlphaFold DB A0A3M2UJ05

References