Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3651542..3652068 | Replicon | chromosome |
| Accession | NZ_CP074407 | ||
| Organism | Escherichia coli strain GDAR2-2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KHW16_RS17705 | Protein ID | WP_000323025.1 |
| Coordinates | 3651781..3652068 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KHW16_RS17700 | Protein ID | WP_000534858.1 |
| Coordinates | 3651542..3651781 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KHW16_RS17670 (3646904) | 3646904..3647393 | + | 490 | Protein_3447 | class I SAM-dependent methyltransferase | - |
| KHW16_RS17675 (3647871) | 3647871..3648292 | + | 422 | Protein_3448 | hypothetical protein | - |
| KHW16_RS17680 (3648948) | 3648948..3649970 | + | 1023 | Protein_3449 | ISNCY family transposase | - |
| KHW16_RS17685 (3650091) | 3650091..3650240 | + | 150 | WP_011443592.1 | protein YdfW | - |
| KHW16_RS17690 (3650677) | 3650677..3651009 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KHW16_RS17695 (3651212) | 3651212..3651517 | - | 306 | WP_001326990.1 | protein YdfV | - |
| KHW16_RS17700 (3651542) | 3651542..3651781 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KHW16_RS17705 (3651781) | 3651781..3652068 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KHW16_RS17710 (3652140) | 3652140..3652295 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KHW16_RS17715 (3652512) | 3652512..3652763 | + | 252 | WP_000980994.1 | protein Rem | - |
| KHW16_RS17720 (3652830) | 3652830..3653108 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| KHW16_RS17725 (3653110) | 3653110..3654159 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| KHW16_RS17730 (3654173) | 3654173..3654925 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KHW16_RS17735 (3655203) | 3655203..3655292 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| KHW16_RS17740 (3655347) | 3655347..3655559 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KHW16_RS17745 (3655860) | 3655860..3656075 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KHW16_RS17750 (3656439) | 3656439..3656609 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| KHW16_RS17755 (3656829) | 3656829..3657044 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3634389..3709872 | 75483 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T202041 WP_000323025.1 NZ_CP074407:3651781-3652068 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T202041 NZ_CP099298:2529019-2529195 [Citrobacter freundii]
GTGAAGCAAAGTGAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA
GTGAAGCAAAGTGAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT202041 WP_000534858.1 NZ_CP074407:3651542-3651781 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT202041 NZ_CP099298:2529242-2529658 [Citrobacter freundii]
ATGCGTTATCCTGTTACTCTAACACCGGCAGTGGAAGGTGGGTTTGTGGTTTCTTTCCCGGATATTCCGGAAGCATTAAC
TCAGGGAAATACTCGCCATGACGCTTTGCAGGCCGCGCAGGCGGCATTGATTACCGCTTTTGAATTCTATTTCGACGACA
ACGAGGCGATTCCACTCCCTTCAGCGGTTAGCGCTGAAGATGACTACGTAGAAATACCGCTGAGCGTTGCGTCTAAGGTT
CTTCTGCTGAATGCCTTCCTTGAATCAAAAATCACCCAGCAGGAGCTGGCGAACAGGATCGGCAGACCTAAGCAGGAGAT
CACCCGTTTATTTGATTTAAAGCACACGACAAAAATTGATGCCGTGCAGATTGCTGCGCGCGCCTTAGGCAAAGAGCTGG
CGTTAACGATGTTGTAA
ATGCGTTATCCTGTTACTCTAACACCGGCAGTGGAAGGTGGGTTTGTGGTTTCTTTCCCGGATATTCCGGAAGCATTAAC
TCAGGGAAATACTCGCCATGACGCTTTGCAGGCCGCGCAGGCGGCATTGATTACCGCTTTTGAATTCTATTTCGACGACA
ACGAGGCGATTCCACTCCCTTCAGCGGTTAGCGCTGAAGATGACTACGTAGAAATACCGCTGAGCGTTGCGTCTAAGGTT
CTTCTGCTGAATGCCTTCCTTGAATCAAAAATCACCCAGCAGGAGCTGGCGAACAGGATCGGCAGACCTAAGCAGGAGAT
CACCCGTTTATTTGATTTAAAGCACACGACAAAAATTGATGCCGTGCAGATTGCTGCGCGCGCCTTAGGCAAAGAGCTGG
CGTTAACGATGTTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|