Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3621576..3622224 Replicon chromosome
Accession NZ_CP074405
Organism Cellulomonas wangleii strain zg-ZUI222

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KG103_RS16610 Protein ID WP_207339585.1
Coordinates 3621784..3622224 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KG103_RS16605 Protein ID WP_207339584.1
Coordinates 3621576..3621794 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KG103_RS16585 (KG103_16585) 3617431..3617805 - 375 WP_207339581.1 glyoxalase superfamily protein -
KG103_RS16590 (KG103_16590) 3618017..3619606 + 1590 WP_207339582.1 fibronectin type III domain-containing protein -
KG103_RS16595 (KG103_16595) 3619712..3620479 + 768 WP_249670646.1 SDR family oxidoreductase -
KG103_RS16600 (KG103_16600) 3620536..3621471 + 936 WP_207339583.1 aldo/keto reductase -
KG103_RS16605 (KG103_16605) 3621576..3621794 + 219 WP_207339584.1 antitoxin Antitoxin
KG103_RS16610 (KG103_16610) 3621784..3622224 + 441 WP_207339585.1 PIN domain-containing protein Toxin
KG103_RS16615 (KG103_16615) 3622266..3622934 - 669 WP_207339586.1 TetR/AcrR family transcriptional regulator -
KG103_RS16620 (KG103_16620) 3623052..3624533 + 1482 WP_207339587.1 MDR family MFS transporter -
KG103_RS16625 (KG103_16625) 3624774..3625754 + 981 WP_213319936.1 polyphosphate polymerase domain-containing protein -
KG103_RS16630 (KG103_16630) 3625751..3626422 + 672 WP_207339588.1 DUF4956 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(8-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 15843.25 Da        Isoelectric Point: 8.1809

>T202020 WP_207339585.1 NZ_CP074405:3621784-3622224 [Cellulomonas wangleii]
VTAEPCYLLDVNVLLALAADAHVHHRAAHRWFADVTAWATTPVTESAFVRLLSTPAVLGRTVLPVEAVAALRQMRTVPGH
RFLPDDASFASTTIDLTRMVGPRQVTDFHLVELARRTGSTLATLDARLRRSLHPADAHLVSVVPAA

Download         Length: 441 bp

>T202020 NZ_CP099261:23490-23801 [Klebsiella aerogenes]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7666.59 Da        Isoelectric Point: 4.9927

>AT202020 WP_207339584.1 NZ_CP074405:3621576-3621794 [Cellulomonas wangleii]
MRTTLEIDDRVLAAARAIAEQQNVSIGRAISDLAERALEGTAPASTVRGFPVFHGPAGHVITDEMVAEHRDG

Download         Length: 219 bp

>AT202020 NZ_CP099261:23798-24217 [Klebsiella aerogenes]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References