Detailed information of TA system TA202019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 507379..507914
• Replicon: chromosome
• Accession: NZ_CP074405
• Organism: Cellulomonas wangleii strain zg-ZUI222

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KG103_RS02540
• Protein ID: WP_089800253.1
• Coordinates: 507379..507645 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KG103_RS02545
• Protein ID: WP_089801006.1
• Coordinates: 507642..507914 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KG103_RS02520 (KG103_02520)	504388..504531	-	144	WP_207340316.1	hypothetical protein	-
KG103_RS02525 (KG103_02525)	505174..505407	-	234	WP_207340317.1	hypothetical protein	-
KG103_RS02530 (KG103_02530)	505803..506006	-	204	WP_207340318.1	hypothetical protein	-
KG103_RS02535 (KG103_02535)	506018..507217	-	1200	WP_207340319.1	RHS repeat-associated core domain-containing protein	-
KG103_RS02540 (KG103_02540)	507379..507645	-	267	WP_089800253.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KG103_RS02545 (KG103_02545)	507642..507914	-	273	WP_089801006.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KG103_RS02550 (KG103_02550)	508011..508661	-	651	WP_207340320.1	hypothetical protein	-
KG103_RS02555 (KG103_02555)	508836..509387	+	552	WP_249670712.1	hypothetical protein	-
KG103_RS02560 (KG103_02560)	509778..509921	-	144	WP_207340321.1	hypothetical protein	-
KG103_RS19000	510400..510531	+	132	WP_256439599.1	hypothetical protein	-
KG103_RS02565 (KG103_02565)	510620..511741	+	1122	WP_207340322.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	505174..523812	18638

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (35-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9711.30 Da
• Isoelectric Point: 11.3019

>T202019 WP_089800253.1 NZ_CP074405:c507645-507379 [Cellulomonas wangleii]
VRYEVQLAPPARRALAGGLPPAVAAAVIEFLSGPLAEAPFRVGKPLRNELEGKWSARRGEYRVIYTINARVVTVTVLTIA
HRRDAYRT

Nucleotide

• Length: 267 bp

>T202019 NZ_CP099260:c4678321-4677980 [Klebsiella aerogenes]
ATGAAAACTCTACCTGCAACAAATCCGCAGGCGGCGACGCTATATCTGTCGCCTGTAGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAAGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGCTCGTATTGATTTCAGGAGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9467.63 Da
• Isoelectric Point: 4.5679

>AT202019 WP_089801006.1 NZ_CP074405:c507914-507642 [Cellulomonas wangleii]
MTTTSLANVKAHLSRFVDSVHDTHERVTITRNGEPAAVLMSPDDLASLEETIAVLSDAAVMAEVREADAAVARGDVTPLA
DVLRARAANA

Nucleotide

• Length: 273 bp

>AT202019 NZ_CP099260:c4678683-4678342 [Klebsiella aerogenes]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTAAAATGGGGACTGAATTGTAATATGACACCTTGCTTTGGTGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGATCGGGCCTGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCACACGTTTTATCCGCCAAATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCAT
GCCCACAGTGTCACCCTGTACCATAACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA