Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 602172..602797 Replicon chromosome
Accession NZ_CP074393
Organism Agrobacterium salinitolerans strain DG3-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KHC17_RS12560 Protein ID WP_142912434.1
Coordinates 602438..602797 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KHC17_RS12555 Protein ID WP_127758200.1
Coordinates 602172..602438 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHC17_RS12525 (KHC17_12525) 597349..597684 - 336 WP_217004406.1 type II toxin-antitoxin system YafQ family toxin -
KHC17_RS12530 (KHC17_12530) 597681..597956 - 276 WP_077982683.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KHC17_RS12535 (KHC17_12535) 598064..598672 + 609 WP_217004846.1 class I SAM-dependent methyltransferase -
KHC17_RS12540 (KHC17_12540) 598848..601430 + 2583 WP_217004407.1 heavy metal translocating P-type ATPase -
KHC17_RS12545 (KHC17_12545) 601427..601849 + 423 WP_142912433.1 Cu(I)-responsive transcriptional regulator -
KHC17_RS12550 (KHC17_12550) 601903..602103 + 201 WP_173988436.1 heavy-metal-associated domain-containing protein -
KHC17_RS12555 (KHC17_12555) 602172..602438 + 267 WP_127758200.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KHC17_RS12560 (KHC17_12560) 602438..602797 + 360 WP_142912434.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KHC17_RS12565 (KHC17_12565) 602867..603136 + 270 WP_077982680.1 type II toxin-antitoxin system ParD family antitoxin -
KHC17_RS12570 (KHC17_12570) 603126..603491 + 366 WP_173988440.1 type II toxin-antitoxin system RelE/ParE family toxin -
KHC17_RS12575 (KHC17_12575) 603488..603736 - 249 WP_217004408.1 hypothetical protein -
KHC17_RS12580 (KHC17_12580) 603913..605514 + 1602 WP_254229149.1 MFS transporter -
KHC17_RS12585 (KHC17_12585) 605590..605763 - 174 WP_077982677.1 hypothetical protein -
KHC17_RS12590 (KHC17_12590) 605832..607547 - 1716 WP_217004409.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-115)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12853.99 Da        Isoelectric Point: 8.2810

>T202013 WP_142912434.1 NZ_CP074393:602438-602797 [Agrobacterium salinitolerans]
MVRSQVPKRGDVYLVDLNPVIGSEIRDEHRCIVITPREINAVGLCLVVPVTTGGLFTRRAGLAVNISGHKTTGVALCNQV
RSMDIVARAAQKKAKYIETLDDATIDEIAGRVISMIDPA

Download         Length: 360 bp

>T202013 NZ_CP099260:839329-839739 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGTATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9394.88 Da        Isoelectric Point: 4.5983

>AT202013 WP_127758200.1 NZ_CP074393:602172-602438 [Agrobacterium salinitolerans]
MTVTTRIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRQEKKRFTLAELLEGADEVAALNAGAREWDEA
PPVGKEAL

Download         Length: 267 bp

>AT202013 NZ_CP099260:839082-839348 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References