Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2607711..2608362 Replicon chromosome
Accession NZ_CP074379
Organism Lacticaseibacillus zeae strain FBL8

Toxin (Protein)


Gene name pemK Uniprot ID K8Q4Y0
Locus tag KG087_RS12310 Protein ID WP_005686631.1
Coordinates 2607711..2608094 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0R1EMB2
Locus tag KG087_RS12315 Protein ID WP_010491246.1
Coordinates 2608114..2608362 (-) Length 83 a.a.

Genomic Context

KG087_RS12290KG087_RS12295KG087_RS12300KG087_RS12305KG087_RS12310KG087_RS12315KG087_RS12320KG087_RS12325KG087_RS12330
Location: 2603055..2604062 (1008 bp)
Type: Others
Protein ID: WP_003662706.1
Location: 2604370..2605740 (1371 bp)
Type: Others
Protein ID: WP_075761421.1
Location: 2605955..2606620 (666 bp)
Type: Others
Protein ID: WP_010491258.1
Location: 2606943..2607641 (699 bp)
Type: Others
Protein ID: WP_010491256.1
Location: 2607711..2608094 (384 bp)
Type: Toxin
Protein ID: WP_005686631.1
Location: 2608114..2608362 (249 bp)
Type: Antitoxin
Protein ID: WP_010491246.1
Location: 2608461..2609600 (1140 bp)
Type: Others
Protein ID: WP_213449874.1
Location: 2609587..2609961 (375 bp)
Type: Others
Protein ID: WP_010491243.1
Location: 2610199..2611707 (1509 bp)
Type: Others
Protein ID: WP_047107145.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KG087_RS12290 (KG087_12290)2603055..2604062+1008WP_003662706.1L-lactate dehydrogenase-
KG087_RS12295 (KG087_12295)2604370..2605740+1371WP_075761421.1L,D-transpeptidase family protein-
KG087_RS12300 (KG087_12300)2605955..2606620+666WP_010491258.1cyclic di-AMP binding protein CbpA-
KG087_RS12305 (KG087_12305)2606943..2607641+699WP_010491256.1L,D-transpeptidase-
KG087_RS12310 (KG087_12310)2607711..2608094-384WP_005686631.1type II toxin-antitoxin system PemK/MazF family toxinToxin
KG087_RS12315 (KG087_12315)2608114..2608362-249WP_010491246.1antitoxinAntitoxin
KG087_RS12320 (KG087_12320)2608461..2609600-1140WP_213449874.1alanine racemase-
KG087_RS12325 (KG087_12325)2609587..2609961-375WP_010491243.1holo-ACP synthase-
KG087_RS12330 (KG087_12330)2610199..2611707-1509WP_047107145.1DEAD/DEAH box helicase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--2598256..2709391111135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13757.03 Da        Isoelectric Point: 10.9764

>T202006 WP_005686631.1 NZ_CP074379:c2608094-2607711 [Lacticaseibacillus zeae]
MDVTVKRGDVFFADLSPVVGSEQGGNRPVLIIQNNVGNHYSPTVIVAAITSKIQKPKMPTHVGLRAKQDGVERNSVILLE
QIRTIDKQRLQARVTALSSAKMAAVDRALAISVGLVSLPKPKTYNKN

Download         Length: 384 bp

>T202006 NZ_CP099254:c4175290-4175003 [Citrobacter freundii]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTGTTCGCTTTGAGGACGCGGT
ACTCGTTTTCGACGACCCCCGGCATTTGTCCAGACAGGATCGTTATGAGAACGGTGAGTACCGGTGGCAGACCATCGGTC
TTGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGT
GCCAGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATGATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8971.07 Da        Isoelectric Point: 4.6061

>AT202006 WP_010491246.1 NZ_CP074379:c2608362-2608114 [Lacticaseibacillus zeae]
MKKQTSVTVTFDAAIKARLDAYCELNDTDTQDVITTAVAKFLQSQAPDINQLISGYVAMGQINTEISHAFSACESEAYAH
IR

Download         Length: 249 bp

>AT202006 NZ_CP099254:c4175016-4174714 [Citrobacter freundii]
ATGAGCATGATTAAACATAAACGTGGCAGCGCATCCGCGCTGAGTGCTCAGCATGAGGCGGAACTGAAGGCGCTGGCGAA
TAAACCGGATGATGATATTGATTATAGCGACATTCCGGTGACTGAAGATGAGCAGTGGTCAGAGGCTAATCGCGGTACGT
TTTTCCGTCCGTTGAAAACTCAGGCATCGGTGCGCATTGATGCCGATGTGATGGAGTGGTTAAAGCGCCCCGGGAAGGGT
TACCAGACGCGGCTAAATGCTATTTTGCGCGAGGCTATGCTGAGAGAGCAAAACAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBK8Q4Y0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0R1EMB2

References