Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-yefM/YoeB-RelB
Location 2358003..2358528 Replicon chromosome
Accession NZ_CP074377
Organism Lacticaseibacillus casei strain FBL6

Toxin (Protein)


Gene name Txe Uniprot ID -
Locus tag KGS74_RS11050 Protein ID WP_191978409.1
Coordinates 2358310..2358528 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KGS74_RS11045 Protein ID WP_049170985.1
Coordinates 2358003..2358278 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGS74_RS11030 (KGS74_11030) 2353948..2354365 - 418 Protein_2142 MarR family transcriptional regulator -
KGS74_RS11035 (KGS74_11035) 2354502..2355146 + 645 WP_049170980.1 HD domain-containing protein -
KGS74_RS11040 (KGS74_11040) 2356235..2357836 + 1602 WP_049170983.1 ABC transporter ATP-binding protein -
KGS74_RS11045 (KGS74_11045) 2358003..2358278 + 276 WP_049170985.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KGS74_RS11050 (KGS74_11050) 2358310..2358528 + 219 WP_191978409.1 Txe/YoeB family addiction module toxin Toxin
KGS74_RS11060 (KGS74_11060) 2358976..2359623 + 648 WP_049170987.1 type II CAAX endopeptidase family protein -
KGS74_RS11065 (KGS74_11065) 2359781..2360752 + 972 WP_049170989.1 TDT family transporter -
KGS74_RS11070 (KGS74_11070) 2360777..2361601 - 825 WP_049170991.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-72)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8486.74 Da        Isoelectric Point: 9.0700

>T202003 WP_191978409.1 NZ_CP074377:2358310-2358528 [Lacticaseibacillus casei]
ISWFEQADKATLRKINRLITSIDRTPFDSLGKPEPLKHGLSGMWSRRITQEHRLIYEIEANTMTIISCRDHY

Download         Length: 219 bp

>T202003 NZ_CP099254:c2420529-2420251 [Citrobacter freundii]
ATGATCATGAACTTCAGACACAAAGGATTGCGCGACTTGTTTCTTCAGGGGCGAACATCAGGCGTGACGGCGAAGCATGT
CCGGAGATTGCGGCACCGACTTGCCGTTATTGATGCAGCGAGCCATGTAACAGATATCAATATGCCTGGTTATAAACTGC
ATGCGTTAACGGGCGATCGCGACGGCGTTTGGTCGATTTCTGTTTCAGGCAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGATGCATATATACTGGATTACGAGGACTATCATTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10223.54 Da        Isoelectric Point: 7.2022

>AT202003 WP_049170985.1 NZ_CP074377:2358003-2358278 [Lacticaseibacillus casei]
MDAVSYSVFRRNLKHYLQAVNDTSTPLLITSRDNEADTAVLMNKRDFDAMQETMRILSNPELMAKIRRGQAQIAAGKTRQ
HDLKDVGGGDD

Download         Length: 276 bp

>AT202003 NZ_CP099254:c2420251-2419967 [Citrobacter freundii]
ATGAAAATGGCTAATCATCCCCGTCCGGGGGATATTATTCAGGAAGCGCTGGATGAGTTAAACGTCAGCCTGCGCGAATT
TGCCAGAGCAATGGAGATTGCCCCCTCAACCGCGAGCCGACTGTTAACGGGCAAGGCAGCATTAACCCCGGAAATGGCGA
TCAAACTTTCAGTGGTGATCGGCAGTTCGCCCGAAATGTGGTTGAATCTGCAGAATGCCTGGAGTCTGGCTGAAGCGCAA
AAAAGCGTGGATATCTCACGTCTGCGCAAACTGGTAGCACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References