Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4481889..4482547 Replicon chromosome
Accession NZ_CP074376
Organism Mycolicibacterium neoaurum strain MN2019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MN2019_RS21290 Protein ID WP_213447571.1
Coordinates 4481889..4482287 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MN2019_RS21295 Protein ID WP_213447572.1
Coordinates 4482284..4482547 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN2019_RS21265 (MN2019_21265) 4477102..4477332 + 231 WP_213447567.1 antitoxin -
MN2019_RS21270 (MN2019_21270) 4477319..4477662 + 344 Protein_4221 type II toxin-antitoxin system PemK/MazF family toxin -
MN2019_RS21275 (MN2019_21275) 4477712..4478704 + 993 WP_213447568.1 ERCC4 domain-containing protein -
MN2019_RS21280 (MN2019_21280) 4478701..4479993 + 1293 WP_213447569.1 DUF2786 domain-containing protein -
MN2019_RS21285 (MN2019_21285) 4480187..4481848 - 1662 WP_213447570.1 SWIM zinc finger family protein -
MN2019_RS21290 (MN2019_21290) 4481889..4482287 - 399 WP_213447571.1 type II toxin-antitoxin system VapC family toxin Toxin
MN2019_RS21295 (MN2019_21295) 4482284..4482547 - 264 WP_213447572.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MN2019_RS21300 (MN2019_21300) 4482664..4483758 - 1095 WP_213447573.1 acyl-CoA desaturase -
MN2019_RS21305 (MN2019_21305) 4483838..4484974 - 1137 Protein_4228 IS3 family transposase -
MN2019_RS21310 (MN2019_21310) 4485281..4486063 - 783 WP_235733207.1 hypothetical protein -
MN2019_RS21315 (MN2019_21315) 4486051..4487358 - 1308 WP_235733208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4462617..4503464 40847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14258.13 Da        Isoelectric Point: 4.4331

>T202002 WP_213447571.1 NZ_CP074376:c4482287-4481889 [Mycolicibacterium neoaurum]
VIVDTSAIIAIALDEPERDALIEALLDAARPRMSAATSVEIAVLMRRLTPEDYRRVERLIERLGIESVPFDGEQAASAVR
AYRDFGRGSGHRAGLNLGDCYAYGLADVTGEPLLFVGDDFGHTDVAVAVRLS

Download         Length: 399 bp

>T202002 NZ_CP099254:2031848-2031951 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9875.09 Da        Isoelectric Point: 5.9111

>AT202002 WP_213447572.1 NZ_CP074376:c4482547-4482284 [Mycolicibacterium neoaurum]
MSLNIKNARTVELVRELARRTGLSQTGAVEEAVRAKLAEVQAGEGREARRTRIDVLLEELDQSVTAEQKKQIRDDERHMY
DDRGVPT

Download         Length: 264 bp

>AT202002 NZ_CP099254:c2031957-2031722 [Citrobacter freundii]
ACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGTCCGCGACCAAAGTGG
CCTGAAAAAAAGGACGATTGTCACCCGCTAGAATGCAAAAACCGCAAGTTCTGCAGCCAGAACGTTGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References