Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 880336..880877 Replicon chromosome
Accession NZ_CP074376
Organism Mycolicibacterium neoaurum strain MN2019

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MN2019_RS04220 Protein ID WP_115282126.1
Coordinates 880581..880877 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MN2019_RS04215 Protein ID WP_115282136.1
Coordinates 880336..880584 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN2019_RS04195 (MN2019_04195) 875336..876454 - 1119 WP_036432593.1 ACR3 family arsenite efflux transporter -
MN2019_RS04200 (MN2019_04200) 876451..876813 - 363 WP_084260096.1 metalloregulator ArsR/SmtB family transcription factor -
MN2019_RS04215 (MN2019_04215) 880336..880584 + 249 WP_115282136.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MN2019_RS04220 (MN2019_04220) 880581..880877 + 297 WP_115282126.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MN2019_RS04225 (MN2019_04225) 881026..881481 - 456 WP_147289450.1 hypothetical protein -
MN2019_RS04230 (MN2019_04230) 881546..882139 - 594 WP_213448618.1 hypothetical protein -
MN2019_RS04235 (MN2019_04235) 882136..884340 - 2205 WP_213448619.1 LuxR family transcriptional regulator -
MN2019_RS04240 (MN2019_04240) 884381..885604 - 1224 WP_213448620.1 O-succinylhomoserine sulfhydrylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 876856..877755 899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(2-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11346.70 Da        Isoelectric Point: 5.1183

>T202000 WP_115282126.1 NZ_CP074376:880581-880877 [Mycolicibacterium neoaurum]
VNRFVLSPAAQADLEQIWDYTCDRWNDDQAESYIREIQRGIELVADNPLIGRSCEEVRPGYRRHRVGSHTLYYRVGASDL
IVVVRVLHKSMDVDQSID

Download         Length: 297 bp

>T202000 NZ_CP099254:c363356-363039 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAGGGATTTAGTAAACGCCGTCCGTTACTTTTACCTGACGATGAGTTTCGTGCCTTTCA
AGAGGCGCTTATTGAAAACCCTGAGGCAGGGGATACTATTGCTGGTACGGGGGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGTAAGCGCAGCGGTATTCGGGTTATCTATTACAACGTGACGCGTAAAGGTCGAATCTATCTGGCTTTGCTC
TATCCTAAGAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCGATATGCTGATTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9126.05 Da        Isoelectric Point: 6.4664

>AT202000 WP_115282136.1 NZ_CP074376:880336-880584 [Mycolicibacterium neoaurum]
VGRNTSFSLDEHFNAFIEGEVASGRYGSASEVVRAALRLLEDRETRLNALRQSLLHGENSGQATSFDFDAFIGRKRAEPR
VQ

Download         Length: 249 bp

>AT202000 NZ_CP099254:c362986-362690 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTACGTATAGAGAAAGGTGAAGAAACACCTAA
ACCTGAACATGTACATACTTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCGGTTGGTGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAACCCACTGGAGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAACCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References