Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2895267..2896065 Replicon chromosome
Accession NZ_CP074366
Organism Escherichia coli strain ZYB62

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0V7WHV8
Locus tag KG092_RS14140 Protein ID WP_001506713.1
Coordinates 2895267..2895644 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag KG092_RS14145 Protein ID WP_001280952.1
Coordinates 2895691..2896065 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KG092_RS14100 (2890274) 2890274..2890765 - 492 WP_001297187.1 DUF1097 domain-containing protein -
KG092_RS14105 (2890867) 2890867..2891421 - 555 WP_001001902.1 molecular chaperone YcdY -
KG092_RS14110 (2891445) 2891445..2892182 - 738 WP_000283664.1 zinc-binding phosphatase -
KG092_RS14115 (2892237) 2892237..2893175 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
KG092_RS14125 (2893646) 2893646..2894488 - 843 WP_001688445.1 DUF4942 domain-containing protein -
KG092_RS14130 (2894573) 2894573..2894770 - 198 WP_000839282.1 DUF957 domain-containing protein -
KG092_RS14135 (2894782) 2894782..2895270 - 489 WP_001470575.1 DUF5983 family protein -
KG092_RS14140 (2895267) 2895267..2895644 - 378 WP_001506713.1 TA system toxin CbtA family protein Toxin
KG092_RS14145 (2895691) 2895691..2896065 - 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KG092_RS14150 (2896228) 2896228..2896449 - 222 WP_041124083.1 DUF987 domain-containing protein -
KG092_RS14155 (2896518) 2896518..2896994 - 477 WP_041124082.1 RadC family protein -
KG092_RS14160 (2897010) 2897010..2897489 - 480 WP_041124081.1 antirestriction protein -
KG092_RS14165 (2897583) 2897583..2897828 - 246 WP_000680583.1 hypothetical protein -
KG092_RS14170 (2897828) 2897828..2898646 - 819 WP_001234621.1 DUF932 domain-containing protein -
KG092_RS14175 (2898746) 2898746..2898853 - 108 WP_108201653.1 hypothetical protein -
KG092_RS14180 (2899015) 2899015..2900085 - 1071 WP_000102643.1 patatin-like phospholipase family protein -
KG092_RS14185 (2900082) 2900082..2900987 - 906 WP_021497799.1 diguanylate cyclase regulator RdcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 2886656..2897828 11172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.26 Da        Isoelectric Point: 7.8045

>T201982 WP_001506713.1 NZ_CP074366:c2895644-2895267 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR

Download         Length: 378 bp

>T201982 NZ_CP099222:2346595-2346873 [Citrobacter freundii]
ATGATCATGAACTTCAGACACAAAGGATTGCGCGACTTGTTTCTTCAGGGGCGAACATCAGGCGTGACGGCGAAGCATGT
CCGACGATTGCGGCACCGACTTGCCGTTATTGATGCAGCGAGCCATGTAACAGATATCAATATGCCTGGTTATAAACTGC
ACGCGTTAACGGGCGATCGCGACGGCGTTTTGTCGATTTCTGTTTCAGGCAACTGGCGTATTACGTTTGAATTCGTCAAT
GGTGATGCATATATACTGGATTACGAGGACTATCATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT201982 WP_001280952.1 NZ_CP074366:c2896065-2895691 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT201982 NZ_CP099222:2346873-2347157 [Citrobacter freundii]
ATGAAAATGGCTAATCATCCCCGTCCGGGGGATATTATTCAGGAAGCGCTGGATGAGTTAAACGTCAGCCTGCGCGAATT
TGCCAGAGCAATGGAGATTGCCCCCTCAACCGCGAGCCGACTGTTAACGGGCAAGGCAGCATTAACCCCGGAAATGGCGA
TCAAACTTTCAGTGGTGATCGGCAGTTCGCCCGAAATGTGGTTGAATCTGCAGAATGCCTGGAGTCTGGCTGAAGCGCAA
AAAAGCGTGGATATCTCACGTCTGCGCAAACTGGTAGCACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V7WHV8

Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References