Detailed information of TA system TA201979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2386850..2388438
• Replicon: chromosome
• Accession: NZ_CP074366
• Organism: Escherichia coli strain ZYB62

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U9XU38
• Locus tag: KG092_RS11590
• Protein ID: WP_001125455.1
• Coordinates: 2387116..2388438 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KG092_RS11585
• Protein ID: WP_001296726.1
• Coordinates: 2386850..2387116 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KG092_RS11585 (2386850)	2386850..2387116	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KG092_RS11590 (2387116)	2387116..2388438	+	1323	WP_001125455.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
KG092_RS11595 (2388620)	2388620..2389729	-	1110	WP_000992809.1	hypothetical protein	-
KG092_RS11600 (2389837)	2389837..2390259	-	423	WP_140241812.1	hypothetical protein	-
KG092_RS11605 (2390348)	2390348..2390530	-	183	WP_001335098.1	hypothetical protein	-
KG092_RS11610 (2390700)	2390700..2391752	+	1053	WP_001734927.1	phage/plasmid replication protein, II/X family	-
KG092_RS11615 (2391764)	2391764..2392081	+	318	WP_001734928.1	DNA-binding protein	-
KG092_RS11620 (2392285)	2392285..2392527	+	243	WP_001734929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49321.93 Da
• Isoelectric Point: 8.8753

>T201979 WP_001125455.1 NZ_CP074366:2387116-2388438 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T201979 NZ_CP099222:817267-817674 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAGTGGATTTCGTTGCTCATTCATGGGCTAGTGGCGGT
GCTTATTTTATTGATGCCATGGCCACTGAGTTACACCCCTTTATGGTTGATTTTGCTCTCTCTGGTGGTGTTCGATTGCG
TGCGCAGTCAGCGCCGTATCAACGCTTGTCAGGGAGAGATTAGACTATTGATGGATGGCCGCCTGCGTTGGCAAGGGCAA
GAGTGGTCGATTGTTAGCGCACCCTGGATGATAAAAACGGGCATGATGTTGCGTTTGCGGTCAAGTACAGGAAAGCGTCA
GCATCTGTGGCTGGCGGCGGACAGCATGGATGATGCCGAATGGCGGGATTTGCGTCGGTTGATATTACAACCGTCAATGC
AGAAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT201979 WP_001296726.1 NZ_CP074366:2386850-2387116 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT201979 NZ_CP099222:817020-817286 [Citrobacter freundii]
ATGGATATTAACAACAAAACACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATTTCGATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGATGACGAAAAGCGCATTTTTATCCGTTTGCTGGAATGTGATGACCCCGATT
TATTTAACTGGTTGATGAATCACGGGAAGCCGGCTGATGCACAGCTGGAGCAAATGGTACGGCTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: U9XU38