Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2324750..2325276 | Replicon | chromosome |
| Accession | NZ_CP074366 | ||
| Organism | Escherichia coli strain ZYB62 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KG092_RS11230 | Protein ID | WP_000323025.1 |
| Coordinates | 2324989..2325276 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KG092_RS11225 | Protein ID | WP_000534858.1 |
| Coordinates | 2324750..2324989 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KG092_RS11190 (2320011) | 2320011..2320262 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| KG092_RS11195 (2320335) | 2320335..2322806 | - | 2472 | WP_000048327.1 | exonuclease | - |
| KG092_RS11200 (2322899) | 2322899..2323090 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| KG092_RS11205 (2323087) | 2323087..2323275 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| KG092_RS11210 (2323359) | 2323359..2323448 | + | 90 | Protein_2189 | hypothetical protein | - |
| KG092_RS11215 (2323885) | 2323885..2324217 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KG092_RS11220 (2324420) | 2324420..2324725 | - | 306 | WP_001326990.1 | protein YdfV | - |
| KG092_RS11225 (2324750) | 2324750..2324989 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KG092_RS11230 (2324989) | 2324989..2325276 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KG092_RS11235 (2325348) | 2325348..2325503 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KG092_RS11240 (2325720) | 2325720..2325971 | + | 252 | WP_000980994.1 | protein Rem | - |
| KG092_RS11245 (2326038) | 2326038..2326316 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| KG092_RS11250 (2326318) | 2326318..2327367 | + | 1050 | WP_001439074.1 | DUF968 domain-containing protein | - |
| KG092_RS11255 (2327381) | 2327381..2328133 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KG092_RS11260 (2328411) | 2328411..2328500 | - | 90 | WP_122985911.1 | hypothetical protein | - |
| KG092_RS11265 (2328555) | 2328555..2328767 | - | 213 | WP_024172454.1 | cold shock-like protein CspF | - |
| KG092_RS11270 (2329066) | 2329066..2329281 | + | 216 | WP_000066485.1 | cold shock-like protein CspB | - |
| KG092_RS11275 (2329645) | 2329645..2329815 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| KG092_RS11280 (2330034) | 2330034..2330249 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2306941..2348458 | 41517 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T201978 WP_000323025.1 NZ_CP074366:2324989-2325276 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T201978 NZ_CP099222:c317469-317152 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAGGGATTTAGTAAACGCCGTCCGTTACTTTTACCTGACGATGAGTTTCGTGCCTTTCA
AGAGGCGCTTATTGAAAACCCTGAGGCAGGGGATACTATCGCTGGTACGGGGGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGTAAGCGCAGCGGTATTCGGGTTATCTATTACAACGTGACGCGTAAAGGTCGAATCTATCTGGCTTTGCTC
TATCCTAAGAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCGATATGCTGATTTAA
ATGTTCACATTTATTGAGCTACAGGGATTTAGTAAACGCCGTCCGTTACTTTTACCTGACGATGAGTTTCGTGCCTTTCA
AGAGGCGCTTATTGAAAACCCTGAGGCAGGGGATACTATCGCTGGTACGGGGGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGTAAGCGCAGCGGTATTCGGGTTATCTATTACAACGTGACGCGTAAAGGTCGAATCTATCTGGCTTTGCTC
TATCCTAAGAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCGATATGCTGATTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT201978 WP_000534858.1 NZ_CP074366:2324750-2324989 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT201978 NZ_CP099222:c317099-316803 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTACGTATAGAGAAAGGTGAAGAAACACCTAA
ACCTGAACATGTGCATACTTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCGGTTGGTGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAACCCACTGGAGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAACCCATTTATAATTAATCAATTAAAAGCAATTTAA
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTACGTATAGAGAAAGGTGAAGAAACACCTAA
ACCTGAACATGTGCATACTTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCGGTTGGTGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAACCCACTGGAGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAACCCATTTATAATTAATCAATTAAAAGCAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|