Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1883534..1884365 | Replicon | chromosome |
| Accession | NZ_CP074366 | ||
| Organism | Escherichia coli strain ZYB62 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | KG092_RS08980 | Protein ID | WP_000854814.1 |
| Coordinates | 1883534..1883908 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | KG092_RS08985 | Protein ID | WP_021557898.1 |
| Coordinates | 1883997..1884365 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KG092_RS08940 (1878930) | 1878930..1880096 | + | 1167 | WP_021523140.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| KG092_RS08945 (1880215) | 1880215..1880688 | + | 474 | WP_001105393.1 | DNA gyrase inhibitor SbmC | - |
| KG092_RS08950 (1880886) | 1880886..1881944 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| KG092_RS08955 (1882116) | 1882116..1882445 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| KG092_RS08960 (1882546) | 1882546..1882869 | - | 324 | WP_225343796.1 | EutP/PduV family microcompartment system protein | - |
| KG092_RS08965 (1882848) | 1882848..1882928 | + | 81 | WP_023441679.1 | hypothetical protein | - |
| KG092_RS08970 (1883217) | 1883217..1883297 | - | 81 | Protein_1752 | hypothetical protein | - |
| KG092_RS08975 (1883343) | 1883343..1883537 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| KG092_RS08980 (1883534) | 1883534..1883908 | - | 375 | WP_000854814.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| KG092_RS08985 (1883997) | 1883997..1884365 | - | 369 | WP_021557898.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KG092_RS08990 (1884455) | 1884455..1884649 | - | 195 | WP_001427456.1 | hypothetical protein | - |
| KG092_RS08995 (1884848) | 1884848..1885417 | + | 570 | WP_000221530.1 | inovirus Gp2 family protein | - |
| KG092_RS09000 (1885677) | 1885677..1886078 | + | 402 | WP_000270974.1 | putative zinc ribbon protein | - |
| KG092_RS09005 (1886066) | 1886066..1886476 | + | 411 | WP_001221617.1 | zinc-ribbon domain-containing protein | - |
| KG092_RS09010 (1886760) | 1886760..1888379 | + | 1620 | Protein_1760 | ISL3 family transposase | - |
| KG092_RS09015 (1888459) | 1888459..1888751 | + | 293 | Protein_1761 | gamma-glutamyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T201969 WP_000854814.1 NZ_CP074366:c1883908-1883534 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T201969 NZ_CP099217:2494228-2494404 [Citrobacter freundii]
GTGAAGCAAAGTGAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA
GTGAAGCAAAGTGAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13537.33 Da Isoelectric Point: 6.4751
>AT201969 WP_021557898.1 NZ_CP074366:c1884365-1883997 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT201969 NZ_CP099217:2494451-2494867 [Citrobacter freundii]
ATGCGTTATCCTGTTACTCTAACACCGGCAGTGGAAGGTGGGTTTGTGGTTTCTTTCCCGGATATTCCGGAAGCATTAAC
TCAGGGAAATACTCGCCATGACGCTTTGCAGGCCGCGCAGGCGGCATTGATTACCGCTTTTGAATTCTATTTCGACGACA
ACGAGGCGATTCCACTCCCTTCGGCGGTTAGCGCTGAAGATGACTACGTAGAAATACCGCTGAGCGTTGCGTCTAAGGTT
CTTCTGCTGAATGCCTTCCTTGAATCAAAAATCACCCAGCAGGAGCTGGCGAACAGGATCGGCAGACCTAAGCAGGAGAT
CACCCGTTTATTTGATTTAAAGCACACGACAAAAATTGATGCCGTGCAGATTGCTGCGCGCGCCTTAGGCAAAGAGCTGG
CGTTAACGATGTTGTAA
ATGCGTTATCCTGTTACTCTAACACCGGCAGTGGAAGGTGGGTTTGTGGTTTCTTTCCCGGATATTCCGGAAGCATTAAC
TCAGGGAAATACTCGCCATGACGCTTTGCAGGCCGCGCAGGCGGCATTGATTACCGCTTTTGAATTCTATTTCGACGACA
ACGAGGCGATTCCACTCCCTTCGGCGGTTAGCGCTGAAGATGACTACGTAGAAATACCGCTGAGCGTTGCGTCTAAGGTT
CTTCTGCTGAATGCCTTCCTTGAATCAAAAATCACCCAGCAGGAGCTGGCGAACAGGATCGGCAGACCTAAGCAGGAGAT
CACCCGTTTATTTGATTTAAAGCACACGACAAAAATTGATGCCGTGCAGATTGCTGCGCGCGCCTTAGGCAAAGAGCTGG
CGTTAACGATGTTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|