Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1404750..1405375 Replicon chromosome
Accession NZ_CP074366
Organism Escherichia coli strain ZYB62

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KG092_RS06800 Protein ID WP_000911330.1
Coordinates 1404977..1405375 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KG092_RS06795 Protein ID WP_000450524.1
Coordinates 1404750..1404977 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KG092_RS06770 (1400554) 1400554..1401024 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KG092_RS06775 (1401024) 1401024..1401596 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KG092_RS06780 (1401742) 1401742..1402620 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KG092_RS06785 (1402637) 1402637..1403671 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KG092_RS06790 (1403884) 1403884..1404597 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KG092_RS06795 (1404750) 1404750..1404977 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KG092_RS06800 (1404977) 1404977..1405375 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
KG092_RS06805 (1405522) 1405522..1406385 + 864 WP_001267508.1 neutral zinc metallopeptidase -
KG092_RS06810 (1406400) 1406400..1408415 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
KG092_RS06815 (1408489) 1408489..1409187 + 699 WP_000679823.1 esterase -
KG092_RS06820 (1409297) 1409297..1409497 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T201968 WP_000911330.1 NZ_CP074366:1404977-1405375 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T201968 NZ_CP099217:2162076-2162179 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT201968 WP_000450524.1 NZ_CP074366:1404750-1404977 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT201968 NZ_CP099217:c2162181-2162041 [Citrobacter freundii]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References