201962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4367283..4367668 Replicon chromosome
Accession NZ_CP074365
Organism Xanthomonas translucens strain CFBP 8304

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0K2ZHE5
Locus tag KCU57_RS19045 Protein ID WP_003469322.1
Coordinates 4367283..4367417 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A1C3TTT1
Locus tag KCU57_RS19050 Protein ID WP_003469323.1
Coordinates 4367516..4367668 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCU57_RS19030 (KCU57_18920) 4363726..4364649 - 924 WP_237649818.1 MBL fold metallo-hydrolase -
KCU57_RS19035 (KCU57_18925) 4364712..4366112 - 1401 WP_003476576.1 tryptophan--tRNA ligase -
KCU57_RS19040 (KCU57_18930) 4366223..4367074 + 852 WP_060744655.1 hypothetical protein -
KCU57_RS19045 (KCU57_18935) 4367283..4367417 - 135 WP_003469322.1 entericidin A/B family lipoprotein Toxin
KCU57_RS19050 (KCU57_18940) 4367516..4367668 - 153 WP_003469323.1 entericidin A/B family lipoprotein Antitoxin
KCU57_RS19055 (KCU57_18945) 4367812..4368735 - 924 WP_237649819.1 arginase -
KCU57_RS19065 (KCU57_18955) 4369123..4369959 - 837 WP_237649820.1 SPOR domain-containing protein -
KCU57_RS19070 (KCU57_18960) 4369969..4370709 - 741 WP_004427869.1 type III pantothenate kinase -
KCU57_RS19075 (KCU57_18965) 4370706..4371701 - 996 WP_237649821.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
KCU57_RS19080 (KCU57_18970) 4371839..4372111 + 273 WP_003476582.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-39)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4604.40 Da        Isoelectric Point: 9.2977

>T201962 WP_003469322.1 NZ_CP074365:c4367417-4367283 [Xanthomonas translucens]
MKRTFAWMLLAMFSVGLLSGCNTVAGAGKDVKSAGEKVEDAAKN

Download         Length: 135 bp

>T201962 NZ_CP099217:279183-279458 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5350.35 Da        Isoelectric Point: 8.1210

>AT201962 WP_003469323.1 NZ_CP074365:c4367668-4367516 [Xanthomonas translucens]
MKRLFTLTMLTLFCAGMLTGCNTMAGAGKDMQKAGDKVETKADDCKDGKC

Download         Length: 153 bp

>AT201962 NZ_CP099217:279455-279814 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTAATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2ZHE5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C3TTT1

References