Detailed information of TA system TA201959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1167168..1167760
• Replicon: chromosome
• Accession: NZ_CP074365
• Organism: Xanthomonas translucens strain CFBP 8304

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A0K2ZF26
• Locus tag: KCU57_RS05025
• Protein ID: WP_053833736.1
• Coordinates: 1167464..1167760 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: KCU57_RS05020
• Protein ID: WP_009580422.1
• Coordinates: 1167168..1167461 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCU57_RS05000 (KCU57_04965)	1162587..1163846	-	1260	WP_237650390.1	type II secretion system F family protein	-
KCU57_RS05005 (KCU57_04970)	1164228..1164677	+	450	WP_053838007.1	pilin	-
KCU57_RS05010 (KCU57_04975)	1164911..1165177	-	267	WP_237650391.1	hypothetical protein	-
KCU57_RS05015 (KCU57_04980)	1165404..1167140	+	1737	WP_237650392.1	type IV-A pilus assembly ATPase PilB	-
KCU57_RS05020 (KCU57_04985)	1167168..1167461	-	294	WP_009580422.1	putative addiction module antidote protein	Antitoxin
KCU57_RS05025 (KCU57_04990)	1167464..1167760	-	297	WP_053833736.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KCU57_RS05030 (KCU57_04995)	1167925..1169313	-	1389	WP_053833737.1	sigma-54 dependent transcriptional regulator	-
KCU57_RS05035 (KCU57_05000)	1169388..1171001	-	1614	WP_003477089.1	ATP-binding protein	-
KCU57_RS05040 (KCU57_05005)	1171245..1172408	+	1164	WP_237650393.1	ADP-forming succinate--CoA ligase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (39-91)

Antitoxin

• Uncharacterized protein HI1420 (5-92)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11167.76 Da
• Isoelectric Point: 10.3355

>T201959 WP_053833736.1 NZ_CP074365:c1167760-1167464 [Xanthomonas translucens]
VIELKQTETFRKWRTKLKDERARTAIALRLTRLAYGHAGDTEAVGQGISELRIHHGPGYRVYFQRRGDTIIVLLCGGDKS
TQAKDIKTAKRLADEWSE

Nucleotide

• Length: 297 bp

>T201959 NZ_CP099140:c4559781-4559248 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTCTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10376.69 Da
• Isoelectric Point: 4.9890

>AT201959 WP_009580422.1 NZ_CP074365:c1167461-1167168 [Xanthomonas translucens]
MTENLTTYDPAEDLNSDQAIADFMAGAFATNDTGFIAHALGIVARAKGMTQIARQTGLSREQLYRSFSEDGNPTLRTTLA
VMKALGIELTAKAAVTH

Nucleotide

• Length: 294 bp

>AT201959 NZ_CP099140:c4560058-4559792 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A0K2ZF26