Detailed information of TA system TA201957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 4013693..4014105
• Replicon: chromosome
• Accession: NZ_CP074364
• Organism: Xanthomonas translucens pv. cerealis strain CFBP 2541

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0K3A2T5
• Locus tag: KHA79_RS17750
• Protein ID: WP_039008097.1
• Coordinates: 4013911..4014105 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KHA79_RS17745
• Protein ID: WP_039008095.1
• Coordinates: 4013693..4013905 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHA79_RS17725 (KHA79_17585)	4009621..4010712	+	1092	WP_080763456.1	beta family protein	-
KHA79_RS17730 (KHA79_17590)	4010624..4011208	-	585	WP_235426752.1	sce7726 family protein	-
KHA79_RS17735 (KHA79_17595)	4011707..4011904	-	198	WP_152613777.1	hypothetical protein	-
KHA79_RS17740 (KHA79_17600)	4011909..4013492	-	1584	WP_080763458.1	anti-phage dCTP deaminase	-
KHA79_RS17745 (KHA79_17605)	4013693..4013905	-	213	WP_039008095.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KHA79_RS17750 (KHA79_17610)	4013911..4014105	-	195	WP_039008097.1	type II toxin-antitoxin system HicA family toxin	Toxin
KHA79_RS17755 (KHA79_17615)	4014218..4016908	-	2691	WP_039008098.1	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-
KHA79_RS17760 (KHA79_17620)	4017144..4019084	+	1941	WP_039009337.1	SpoIIE family protein phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	htpB	4005685..4060602	54917

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7031.08 Da
• Isoelectric Point: 11.2875

>T201957 WP_039008097.1 NZ_CP074364:c4014105-4013911 [Xanthomonas translucens pv. cerealis]
MPPKIRDVLQQLRDAGWQQVGQTGSHRQFKHPVYPGRVTVAGKPSDDVAPGTLNSILKQAGLKR

Nucleotide

• Length: 195 bp

>T201957 NZ_CP099140:c3834197-3833880 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7420.36 Da
• Isoelectric Point: 3.9389

>AT201957 WP_039008095.1 NZ_CP074364:c4013905-4013693 [Xanthomonas translucens pv. cerealis]
MRYAVVIEQAGNNYSAYVPDLPGCVATGATTAEVEGLIREAIELHLAGMREDGEVIPLPSSQVEYVNVAA

Nucleotide

• Length: 213 bp

>AT201957 NZ_CP099140:c3833887-3833600 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: A0A0K3A2T5