Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4301666..4302051 Replicon chromosome
Accession NZ_CP074363
Organism Xanthomonas translucens pv. secalis strain CFBP 2539

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0K2ZHE5
Locus tag KAF26_RS18715 Protein ID WP_003469322.1
Coordinates 4301666..4301800 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A1C3TTT1
Locus tag KAF26_RS18720 Protein ID WP_003469323.1
Coordinates 4301899..4302051 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF26_RS18700 (KAF26_18560) 4298090..4299013 - 924 WP_003469319.1 MBL fold metallo-hydrolase -
KAF26_RS18705 (KAF26_18565) 4299090..4300490 - 1401 WP_003469320.1 tryptophan--tRNA ligase -
KAF26_RS18710 (KAF26_18570) 4300601..4301455 + 855 WP_003469321.1 hypothetical protein -
KAF26_RS18715 (KAF26_18575) 4301666..4301800 - 135 WP_003469322.1 entericidin A/B family lipoprotein Toxin
KAF26_RS18720 (KAF26_18580) 4301899..4302051 - 153 WP_003469323.1 entericidin A/B family lipoprotein Antitoxin
KAF26_RS18725 (KAF26_18585) 4302196..4303118 - 923 Protein_3690 arginase -
KAF26_RS18735 (KAF26_18595) 4303524..4304342 - 819 WP_047325438.1 SPOR domain-containing protein -
KAF26_RS18740 (KAF26_18600) 4304352..4305092 - 741 WP_003469293.1 type III pantothenate kinase -
KAF26_RS18745 (KAF26_18605) 4305089..4306108 - 1020 WP_162489024.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
KAF26_RS18750 (KAF26_18610) 4306213..4306476 + 264 WP_038238001.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-39)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4604.40 Da        Isoelectric Point: 9.2977

>T201953 WP_003469322.1 NZ_CP074363:c4301800-4301666 [Xanthomonas translucens pv. secalis]
MKRTFAWMLLAMFSVGLLSGCNTVAGAGKDVKSAGEKVEDAAKN

Download         Length: 135 bp

>T201953 NZ_CP099140:727182-727667 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5350.35 Da        Isoelectric Point: 8.1210

>AT201953 WP_003469323.1 NZ_CP074363:c4302051-4301899 [Xanthomonas translucens pv. secalis]
MKRLFTLTMLTLFCAGMLTGCNTMAGAGKDMQKAGDKVETKADDCKDGKC

Download         Length: 153 bp

>AT201953 NZ_CP099140:726892-727185 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2ZHE5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C3TTT1

References