Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 3561832..3562337 Replicon chromosome
Accession NZ_CP074363
Organism Xanthomonas translucens pv. secalis strain CFBP 2539

Toxin (Protein)


Gene name relE Uniprot ID A0A2S0NY60
Locus tag KAF26_RS15225 Protein ID WP_003468814.1
Coordinates 3562080..3562337 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A1C3TRJ9
Locus tag KAF26_RS15220 Protein ID WP_003468816.1
Coordinates 3561832..3562083 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF26_RS15190 (KAF26_15060) 3557694..3557984 - 291 WP_003468827.1 hypothetical protein -
KAF26_RS15195 (KAF26_15065) 3558319..3558594 + 276 WP_003468826.1 hypothetical protein -
KAF26_RS15200 (KAF26_15070) 3558762..3559457 - 696 WP_222936868.1 hypothetical protein -
KAF26_RS15205 (KAF26_15075) 3559620..3560069 - 450 WP_003468823.1 nuclear transport factor 2 family protein -
KAF26_RS15210 (KAF26_15080) 3560193..3560915 + 723 WP_003468821.1 helix-turn-helix transcriptional regulator -
KAF26_RS15215 (KAF26_15085) 3560912..3561676 - 765 WP_003468819.1 DNA-formamidopyrimidine glycosylase family protein -
KAF26_RS15220 (KAF26_15090) 3561832..3562083 + 252 WP_003468816.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KAF26_RS15225 (KAF26_15095) 3562080..3562337 + 258 WP_003468814.1 Txe/YoeB family addiction module toxin Toxin
KAF26_RS15235 (KAF26_15105) 3562630..3562983 - 354 WP_003468813.1 PilZ domain-containing protein -
KAF26_RS15240 (KAF26_15110) 3562980..3563957 - 978 WP_003468812.1 DNA polymerase III subunit delta' -
KAF26_RS15245 (KAF26_15115) 3563954..3564622 - 669 WP_003468811.1 dTMP kinase -
KAF26_RS15250 (KAF26_15120) 3564619..3565686 - 1068 WP_170873989.1 endolytic transglycosylase MltG -
KAF26_RS15255 (KAF26_15125) 3565756..3567105 - 1350 WP_003468809.1 aminodeoxychorismate synthase component I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10173.68 Da        Isoelectric Point: 9.6587

>T201952 WP_003468814.1 NZ_CP074363:3562080-3562337 [Xanthomonas translucens pv. secalis]
VTLQFSDNAWEDYLYWQQTDKKMLKRINDLIKAIQRDPFQGVGKPEPLRHALAGYWSRRINDEHRIVYKVEAGVLLIAQV
RYHYV

Download         Length: 258 bp

>T201952 NZ_CP099140:322450-322818 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACCGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9281.56 Da        Isoelectric Point: 5.1186

>AT201952 WP_003468816.1 NZ_CP074363:3561832-3562083 [Xanthomonas translucens pv. secalis]
MDTITYSAARAALADTMERVVNNHEPVIITRSREQSVVMLSLEDYKAMEETAYLLRSPKSAQRLLESIAQLEAGRGKARD
LAE

Download         Length: 252 bp

>AT201952 NZ_CP099140:322232-322453 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S0NY60

Antitoxin

Source ID Structure
AlphaFold DB A0A1C3TRJ9

References