201941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3409903..3410521 Replicon chromosome
Accession NZ_CP074359
Organism Escherichia coli strain XJ6.2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFQ22_RS16620 Protein ID WP_001291435.1
Coordinates 3410303..3410521 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KFQ22_RS16615 Protein ID WP_000344800.1
Coordinates 3409903..3410277 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ22_RS16605 (3404992) 3404992..3406185 + 1194 WP_275877749.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFQ22_RS16610 (3406208) 3406208..3409357 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KFQ22_RS16615 (3409903) 3409903..3410277 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KFQ22_RS16620 (3410303) 3410303..3410521 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFQ22_RS16625 (3410693) 3410693..3411244 + 552 WP_000102564.1 maltose O-acetyltransferase -
KFQ22_RS16630 (3411360) 3411360..3411830 + 471 WP_000136192.1 YlaC family protein -
KFQ22_RS16635 (3411994) 3411994..3413544 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFQ22_RS16640 (3413586) 3413586..3413939 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KFQ22_RS16650 (3414318) 3414318..3414629 + 312 WP_000409911.1 MGMT family protein -
KFQ22_RS16655 (3414660) 3414660..3415232 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T201941 WP_001291435.1 NZ_CP074359:3410303-3410521 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T201941 NZ_CP099128:251407-251682 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT201941 WP_000344800.1 NZ_CP074359:3409903-3410277 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT201941 NZ_CP099128:251679-252038 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References