Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2258132..2258658 | Replicon | chromosome |
| Accession | NZ_CP074359 | ||
| Organism | Escherichia coli strain XJ6.2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KFQ22_RS10935 | Protein ID | WP_000323025.1 |
| Coordinates | 2258371..2258658 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KFQ22_RS10930 | Protein ID | WP_000534858.1 |
| Coordinates | 2258132..2258371 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFQ22_RS10900 (2253684) | 2253684..2254105 | + | 422 | Protein_2128 | hypothetical protein | - |
| KFQ22_RS10905 (2254761) | 2254761..2255783 | + | 1023 | Protein_2129 | ISNCY family transposase | - |
| KFQ22_RS10910 (2255904) | 2255904..2256053 | + | 150 | WP_011443592.1 | protein YdfW | - |
| KFQ22_RS10915 (2256490) | 2256490..2256822 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KFQ22_RS10920 (2257030) | 2257030..2257727 | + | 698 | WP_223216367.1 | IS1 family transposase | - |
| KFQ22_RS10925 (2257802) | 2257802..2258107 | - | 306 | WP_001326990.1 | protein YdfV | - |
| KFQ22_RS10930 (2258132) | 2258132..2258371 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KFQ22_RS10935 (2258371) | 2258371..2258658 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KFQ22_RS10940 (2258730) | 2258730..2258885 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KFQ22_RS10945 (2259102) | 2259102..2259353 | + | 252 | WP_000980994.1 | protein Rem | - |
| KFQ22_RS10950 (2259420) | 2259420..2259698 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| KFQ22_RS10955 (2259700) | 2259700..2260749 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| KFQ22_RS10960 (2260763) | 2260763..2261515 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KFQ22_RS10965 (2261793) | 2261793..2261882 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| KFQ22_RS10970 (2261937) | 2261937..2262149 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KFQ22_RS10975 (2262450) | 2262450..2262665 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KFQ22_RS10980 (2263029) | 2263029..2263199 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| KFQ22_RS10985 (2263419) | 2263419..2263634 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2241112..2273846 | 32734 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T201938 WP_000323025.1 NZ_CP074359:2258371-2258658 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T201938 NZ_CP099084:4397317-4397604 [Citrobacter freundii]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTGGATAAAACCATTCAGCAGCAGTTTGC
CAAAAAACTCAAGAAATGCTGTGAAAATCCGCATGTCCCCTCCGAGAAGCTCGGGGGAATAAAAGATTGCTATAAAATCA
AACTACGCACTTCAGGGTTCCGTCTTGTTTATCAAGTTATTGACGAAACACTGGTCATCGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTTTATAATCTTGCCAGCGAAAGACTACGTTAA
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTGGATAAAACCATTCAGCAGCAGTTTGC
CAAAAAACTCAAGAAATGCTGTGAAAATCCGCATGTCCCCTCCGAGAAGCTCGGGGGAATAAAAGATTGCTATAAAATCA
AACTACGCACTTCAGGGTTCCGTCTTGTTTATCAAGTTATTGACGAAACACTGGTCATCGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTTTATAATCTTGCCAGCGAAAGACTACGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT201938 WP_000534858.1 NZ_CP074359:2258132-2258371 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT201938 NZ_CP099084:4397069-4397320 [Citrobacter freundii]
ATGCCACATATCATTTTAAGCGACACCACCGCCAGCGTGAGTGAGCTAAAAAAGAACCCGATGGCGACTGTTAGCGCAGG
GGATGGGTTTCCGGTCGCAATCCTGAACCGTAACCAGCCCGCCTTTTATTGTGTTCCCGCTGAGCTTTACGAAAAAATGC
TTGATGCGCTGGACGATCAGCAACTGGTTAAATTAGTCCATGAACGGAGCCAACAGCCACTGGTGGATGTTGATCTGGAC
AGCTATTTATGA
ATGCCACATATCATTTTAAGCGACACCACCGCCAGCGTGAGTGAGCTAAAAAAGAACCCGATGGCGACTGTTAGCGCAGG
GGATGGGTTTCCGGTCGCAATCCTGAACCGTAACCAGCCCGCCTTTTATTGTGTTCCCGCTGAGCTTTACGAAAAAATGC
TTGATGCGCTGGACGATCAGCAACTGGTTAAATTAGTCCATGAACGGAGCCAACAGCCACTGGTGGATGTTGATCTGGAC
AGCTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|