Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3552080..3552698 Replicon chromosome
Accession NZ_CP074356
Organism Escherichia coli strain XJ6.1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFQ18_RS16925 Protein ID WP_001291435.1
Coordinates 3552480..3552698 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KFQ18_RS16920 Protein ID WP_000344800.1
Coordinates 3552080..3552454 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ18_RS16910 (3547169) 3547169..3548362 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFQ18_RS16915 (3548385) 3548385..3551534 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
KFQ18_RS16920 (3552080) 3552080..3552454 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KFQ18_RS16925 (3552480) 3552480..3552698 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFQ18_RS16930 (3552870) 3552870..3553418 + 549 Protein_3310 maltose O-acetyltransferase -
KFQ18_RS16935 (3553538) 3553538..3554008 + 471 WP_000136192.1 YlaC family protein -
KFQ18_RS16940 (3554172) 3554172..3555722 + 1551 WP_001305493.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFQ18_RS16945 (3555764) 3555764..3556117 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KFQ18_RS16955 (3556496) 3556496..3556807 + 312 WP_000409911.1 MGMT family protein -
KFQ18_RS16960 (3556838) 3556838..3557410 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T201909 WP_001291435.1 NZ_CP074356:3552480-3552698 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T201909 NZ_CP098834:4769130-4769441 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT201909 WP_000344800.1 NZ_CP074356:3552080-3552454 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT201909 NZ_CP098834:4769438-4769884 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References