Detailed information of TA system TA201908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3133327..3134032
• Replicon: chromosome
• Accession: NZ_CP074356
• Organism: Escherichia coli strain XJ6.1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: KFQ18_RS15075
• Protein ID: WP_000539521.1
• Coordinates: 3133327..3133713 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KFQ18_RS15080
• Protein ID: WP_001280945.1
• Coordinates: 3133703..3134032 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFQ18_RS15055 (3129331)	3129331..3129957	+	627	WP_001295292.1	glutathione S-transferase GstB	-
KFQ18_RS15060 (3129954)	3129954..3131069	-	1116	WP_000555051.1	aldose sugar dehydrogenase YliI	-
KFQ18_RS15065 (3131180)	3131180..3131563	-	384	WP_219382174.1	biofilm formation regulator BssR	-
KFQ18_RS15070 (3131776)	3131776..3133101	+	1326	WP_275877300.1	30S ribosomal protein S12 methylthiotransferase RimO	-
KFQ18_RS15075 (3133327)	3133327..3133713	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KFQ18_RS15080 (3133703)	3133703..3134032	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
KFQ18_RS15085 (3134102)	3134102..3135430	-	1329	WP_000086873.1	GGDEF domain-containing protein	-
KFQ18_RS15090 (3135438)	3135438..3137786	-	2349	WP_275877301.1	EAL domain-containing protein	-
KFQ18_RS15095 (3137964)	3137964..3138875	-	912	WP_001236035.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T201908 WP_000539521.1 NZ_CP074356:3133327-3133713 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T201908 NZ_CP098834:c4767897-4767586 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT201908 WP_001280945.1 NZ_CP074356:3133703-3134032 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT201908 NZ_CP098834:c4767585-4767295 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A829GCT6