Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873864..874518 Replicon chromosome
Accession NZ_CP074356
Organism Escherichia coli strain XJ6.1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KFQ18_RS04240 Protein ID WP_275877499.1
Coordinates 874111..874518 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KFQ18_RS04235 Protein ID WP_000354046.1
Coordinates 873864..874130 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ18_RS04210 (869147) 869147..869890 + 744 WP_032353540.1 SDR family oxidoreductase -
KFQ18_RS04215 (869952) 869952..871385 - 1434 WP_275877498.1 6-phospho-beta-glucosidase BglA -
KFQ18_RS04220 (871430) 871430..871741 + 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
KFQ18_RS04225 (871905) 871905..872564 + 660 WP_000250269.1 hemolysin III family protein -
KFQ18_RS04230 (872641) 872641..873621 - 981 WP_001587401.1 tRNA-modifying protein YgfZ -
KFQ18_RS04235 (873864) 873864..874130 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KFQ18_RS04240 (874111) 874111..874518 + 408 WP_275877499.1 protein YgfX Toxin
KFQ18_RS04245 (874558) 874558..875079 - 522 WP_001055874.1 flavodoxin FldB -
KFQ18_RS04250 (875191) 875191..876087 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KFQ18_RS04255 (876112) 876112..876822 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFQ18_RS04260 (876828) 876828..878561 + 1734 WP_000813175.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.05 Da        Isoelectric Point: 11.7518

>T201893 WP_275877499.1 NZ_CP074356:874111-874518 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAKWRDLRRILLQQETQR

Download         Length: 408 bp

>T201893 NZ_CP098832:55621-56037 [Salmonella enterica subsp. enterica serovar Indiana]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT201893 WP_000354046.1 NZ_CP074356:873864-874130 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201893 NZ_CP098832:55394-55624 [Salmonella enterica subsp. enterica serovar Indiana]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References