Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 277736..278322 Replicon chromosome
Accession NZ_CP074356
Organism Escherichia coli strain XJ6.1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag KFQ18_RS01260 Protein ID WP_042014162.1
Coordinates 277736..277966 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KFQ18_RS01265 Protein ID WP_000593555.1
Coordinates 277963..278322 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ18_RS01250 (273773) 273773..276508 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
KFQ18_RS01255 (276508) 276508..277632 + 1125 WP_001314210.1 ABC transporter permease -
KFQ18_RS01260 (277736) 277736..277966 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
KFQ18_RS01265 (277963) 277963..278322 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KFQ18_RS01270 (278442) 278442..278843 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
KFQ18_RS01275 (278849) 278849..279655 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
KFQ18_RS01280 (279652) 279652..280416 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
KFQ18_RS01285 (280416) 280416..281249 - 834 WP_042099188.1 nickel ABC transporter permease subunit NikC -
KFQ18_RS01290 (281246) 281246..282190 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T201891 WP_042014162.1 NZ_CP074356:277736-277966 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T201891 NZ_CP098831:c4615500-4615126 [Salmonella enterica subsp. enterica serovar Indiana]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT201891 WP_000593555.1 NZ_CP074356:277963-278322 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT201891 NZ_CP098831:c4615742-4615500 [Salmonella enterica subsp. enterica serovar Indiana]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References