Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3408680..3409298 Replicon chromosome
Accession NZ_CP074354
Organism Escherichia coli strain XJ5.2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFQ11_RS17035 Protein ID WP_001291435.1
Coordinates 3409080..3409298 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag KFQ11_RS17030 Protein ID WP_282317765.1
Coordinates 3408680..3409054 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ11_RS17020 (3403769) 3403769..3404962 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFQ11_RS17025 (3404985) 3404985..3408134 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KFQ11_RS17030 (3408680) 3408680..3409054 + 375 WP_282317765.1 Hha toxicity modulator TomB Antitoxin
KFQ11_RS17035 (3409080) 3409080..3409298 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFQ11_RS17040 (3409470) 3409470..3410021 + 552 WP_000102564.1 maltose O-acetyltransferase -
KFQ11_RS17045 (3410137) 3410137..3410607 + 471 WP_000136192.1 YlaC family protein -
KFQ11_RS17050 (3410771) 3410771..3412321 + 1551 WP_001469946.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFQ11_RS17055 (3412363) 3412363..3412716 - 354 Protein_3340 DUF1428 family protein -
KFQ11_RS17065 (3413095) 3413095..3413406 + 312 WP_000409911.1 MGMT family protein -
KFQ11_RS17070 (3413437) 3413437..3414009 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T201883 WP_001291435.1 NZ_CP074354:3409080-3409298 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T201883 NZ_CP098831:812669-813082 [Salmonella enterica subsp. enterica serovar Indiana]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCATCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14586.43 Da        Isoelectric Point: 4.9091

>AT201883 WP_282317765.1 NZ_CP074354:3408680-3409054 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQINEYL
DDTFMLFSSYGINMQDLQKWRKSSNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT201883 NZ_CP098831:812422-812688 [Salmonella enterica subsp. enterica serovar Indiana]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References