Detailed information of TA system TA201882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2365532..2366170
• Replicon: chromosome
• Accession: NZ_CP074354
• Organism: Escherichia coli strain XJ5.2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2X7GI71
• Locus tag: KFQ11_RS11790
• Protein ID: WP_032231106.1
• Coordinates: 2365994..2366170 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KFQ11_RS11785
• Protein ID: WP_001270286.1
• Coordinates: 2365532..2365948 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFQ11_RS11765 (2360684)	2360684..2361625	-	942	WP_001251331.1	ABC transporter permease	-
KFQ11_RS11770 (2361626)	2361626..2362639	-	1014	WP_282317605.1	ABC transporter ATP-binding protein	-
KFQ11_RS11775 (2362657)	2362657..2363802	-	1146	WP_000047425.1	ABC transporter substrate-binding protein	-
KFQ11_RS11780 (2364047)	2364047..2365453	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
KFQ11_RS11785 (2365532)	2365532..2365948	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
KFQ11_RS11790 (2365994)	2365994..2366170	-	177	WP_032231106.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
KFQ11_RS11795 (2366392)	2366392..2366622	+	231	WP_000494244.1	YncJ family protein	-
KFQ11_RS11800 (2366714)	2366714..2368675	-	1962	WP_001491066.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
KFQ11_RS11805 (2368748)	2368748..2369284	-	537	WP_000429151.1	DNA-binding transcriptional regulator SutR	-
KFQ11_RS11810 (2369376)	2369376..2370548	+	1173	WP_244578628.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6680.72 Da
• Isoelectric Point: 10.9223

>T201882 WP_032231106.1 NZ_CP074354:c2366170-2365994 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPCHPSDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T201882 NZ_CP098829:4798783-4799094 [Salmonella enterica subsp. enterica serovar Indiana]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT201882 WP_001270286.1 NZ_CP074354:c2365948-2365532 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT201882 NZ_CP098829:4799091-4799537 [Salmonella enterica subsp. enterica serovar Indiana]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2X7GI71