Detailed information of TA system TA201855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 166232..166866
• Replicon: chromosome
• Accession: NZ_CP074352
• Organism: Siccibacter colletis strain YSD YN2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KFZ77_RS00820
• Protein ID: WP_031521986.1
• Coordinates: 166232..166636 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KFZ77_RS00825
• Protein ID: WP_031521984.1
• Coordinates: 166636..166866 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFZ77_RS00790 (KFZ77_00795)	161887..162879	+	993	WP_264385193.1	dipeptide ABC transporter ATP-binding protein	-
KFZ77_RS00795 (KFZ77_00800)	162866..163882	+	1017	WP_031521997.1	peptide ABC transporter ATP-binding protein	-
KFZ77_RS00800 (KFZ77_00805)	164205..164462	+	258	WP_264385194.1	helix-turn-helix domain-containing protein	-
KFZ77_RS00805 (KFZ77_00810)	164447..164758	+	312	WP_264385195.1	HipA N-terminal domain-containing protein	-
KFZ77_RS00810 (KFZ77_00815)	164758..165801	+	1044	WP_264385196.1	HipA domain-containing protein	-
KFZ77_RS00815 (KFZ77_00820)	165878..166063	-	186	WP_264385197.1	toxin-antitoxin system HicB family antitoxin	-
KFZ77_RS00820 (KFZ77_00825)	166232..166636	-	405	WP_031521986.1	tRNA(fMet)-specific endonuclease VapC	Toxin
KFZ77_RS00825 (KFZ77_00830)	166636..166866	-	231	WP_031521984.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KFZ77_RS00830 (KFZ77_00835)	167050..168735	-	1686	WP_031521983.1	cellulose biosynthesis protein BcsG	-
KFZ77_RS00835 (KFZ77_00840)	168728..168922	-	195	WP_031521981.1	cellulose biosynthesis protein BcsF	-
KFZ77_RS00840 (KFZ77_00845)	168919..170484	-	1566	WP_264385198.1	cellulose biosynthesis protein BcsE	-
KFZ77_RS00845 (KFZ77_00850)	170657..170842	+	186	WP_264385199.1	cellulose biosynthesis protein BcsR	-
KFZ77_RS00850 (KFZ77_00855)	170854..171588	+	735	WP_264385200.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14982.20 Da
• Isoelectric Point: 7.8540

>T201855 WP_031521986.1 NZ_CP074352:c166636-166232 [Siccibacter colletis]
MLKFMLDTNICIFTIKNKPQIVRDAFNKYYGQMCISTVTLMELIYGAEKSQNPERNLAVVEGFAARLDVLTFDNDAATHT
GQIRADLAKKGTPIGAWDNMIAGHARSRGLIVVTNNTREFERVSGLRTEDWIAG

Nucleotide

• Length: 405 bp

>T201855 NZ_CP098801:235251-235544 [Rhizobium anhuiense bv. trifolii]
GTGAAGCTTATCTGGTCTGCGTTCGCGTTATCGGATCGCGACGCCATTTTCACATACATAGAAGCAGAAAATCCGTCAGC
CGCCATACTGGTCGACGAACGGATCGTTGCTGCCGTCCGTCGGTTGGTGGATTTTCCCGCGAGCGGTCGTGTTGGCAGAA
TTGCTGGCACCCGCGAACTGGCAATTAACGGCACGCCGTACGTCGCGGCGTATGCAATTACCGAAACAGCGGTTCGTATT
CTTCGCGTCCTCCATGGCGCGCAGGAATGGCCAGACACTTTGCCAACGCGCTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8645.55 Da
• Isoelectric Point: 4.4091

>AT201855 WP_031521984.1 NZ_CP074352:c166866-166636 [Siccibacter colletis]
MEKTTVFRSNRSQAVRLPKAVALPEDVKNVEIVAIGRTRIITPAGEGWDTWFNGDSVTSDYMSDRDQPDDQTREEF

Nucleotide

• Length: 231 bp

>AT201855 NZ_CP098801:234946-235254 [Rhizobium anhuiense bv. trifolii]
ATGGCTGCAAATGCACTGGTACAAACTCGTATCGATGCCGATGTTCGGGATCGTGCCTCCGCAGTGCTTGGAAATATGGG
GCTGACCGTATCTGATGCGGTTCGTATCTTACTCACCCGAACGGCCAACGAAGGTGCGCTGCCGCTGGAGCTTCTTTCAG
GCAGCGAGGCCCACGACGCTTGGTTTCGCACCAAGGTACTTGAAGCGCTGAACGATATTCGACCGGACGTCTCAGATGAT
GAAGTCGAGGCGCATTTCGCTGAACGTCGAGCGGCAGCTCGCCTTAACGCTGGTGCGCGCAAATCGTGA