Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-PrpA/PRK09812-CC2985
Location 80849..81629 Replicon chromosome
Accession NZ_CP074352
Organism Siccibacter colletis strain YSD YN2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KFZ77_RS00425 Protein ID WP_264385150.1
Coordinates 80849..81217 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag KFZ77_RS00430 Protein ID WP_031522118.1
Coordinates 81363..81629 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ77_RS00405 (KFZ77_00410) 75937..76947 + 1011 WP_031522126.1 LacI family DNA-binding transcriptional regulator -
KFZ77_RS00410 (KFZ77_00415) 77050..79173 + 2124 WP_264385148.1 alpha-galactosidase -
KFZ77_RS00415 (KFZ77_00420) 79225..80499 + 1275 WP_031522123.1 MFS transporter -
KFZ77_RS00420 (KFZ77_00425) 80618..80848 + 231 WP_264385149.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
KFZ77_RS00425 (KFZ77_00430) 80849..81217 + 369 WP_264385150.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFZ77_RS00430 (KFZ77_00435) 81363..81629 + 267 WP_031522118.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KFZ77_RS00435 (KFZ77_00440) 81610..81888 + 279 WP_264385151.1 type II toxin-antitoxin system RelE/ParE family toxin -
KFZ77_RS00440 (KFZ77_00445) 81948..82262 - 315 WP_264385152.1 L-rhamnose mutarotase -
KFZ77_RS00445 (KFZ77_00450) 82259..83407 - 1149 WP_264385153.1 lactaldehyde reductase -
KFZ77_RS00450 (KFZ77_00455) 83485..84489 - 1005 WP_264385154.1 ABC transporter permease -
KFZ77_RS00455 (KFZ77_00460) 84486..85493 - 1008 WP_264386223.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-116)

Antitoxin

Antitoxin ParD

(1-84)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13131.21 Da        Isoelectric Point: 8.4956

>T201852 WP_264385150.1 NZ_CP074352:80849-81217 [Siccibacter colletis]
MAPGMKFPHKGEIWHVNGDPTKGREFQGPHYYLVITDKQLVKALGVATCVPITTGGSAARSAQVTVMLDGGSTDKGSVTG
VALCYMLRSMDLKARGARYHSTVEAAVMREILDKVVDLIDPQ

Download         Length: 369 bp

>T201852 NZ_CP098796:c89478-89176 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10111.19 Da        Isoelectric Point: 4.6533

>AT201852 WP_031522118.1 NZ_CP074352:81363-81629 [Siccibacter colletis]
MARTMTVDLGEELRGFVESLIATGDYRTQSEVIRDSLRLLREQQAQSHLQQLRALINEGVNSGAPQEWKQDAFLQNLKAR
DRHDDETD

Download         Length: 267 bp

>AT201852 NZ_CP098796:c89175-88894 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References