Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 64665..65284 Replicon chromosome
Accession NZ_CP074352
Organism Siccibacter colletis strain YSD YN2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KFZ77_RS00345 Protein ID WP_264385143.1
Coordinates 64910..65284 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KFZ77_RS00340 Protein ID WP_264385142.1
Coordinates 64665..64907 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ77_RS00320 (KFZ77_00325) 60487..62811 + 2325 WP_264385138.1 alpha-xylosidase -
KFZ77_RS00325 (KFZ77_00330) 62958..63659 - 702 WP_264385139.1 winged helix-turn-helix domain-containing protein -
KFZ77_RS00330 (KFZ77_00335) 63662..64054 - 393 WP_264385140.1 amino acid-binding protein -
KFZ77_RS00335 (KFZ77_00340) 64059..64370 - 312 WP_264385141.1 antibiotic biosynthesis monooxygenase -
KFZ77_RS00340 (KFZ77_00345) 64665..64907 + 243 WP_264385142.1 CopG family transcriptional regulator Antitoxin
KFZ77_RS00345 (KFZ77_00350) 64910..65284 + 375 WP_264385143.1 type II toxin-antitoxin system VapC family toxin Toxin
KFZ77_RS00350 (KFZ77_00355) 65322..66251 - 930 WP_264385144.1 formate dehydrogenase accessory protein FdhE -
KFZ77_RS00355 (KFZ77_00360) 66248..66883 - 636 WP_031522145.1 formate dehydrogenase cytochrome b556 subunit -
KFZ77_RS00360 (KFZ77_00365) 66880..67782 - 903 WP_031522144.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-49)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13748.97 Da        Isoelectric Point: 6.7260

>T201851 WP_264385143.1 NZ_CP074352:64910-65284 [Siccibacter colletis]
MEGVAVFDTNILIDLFSGHQQAAEVMEQYPINRGISLMTWIEVMVGAKKHGQEIRTREVLEAFDVLPISAAVAERSVMIR
QQHGMKLPDAIILATAQVNSRLLVTRNSKDFAGISGVTIPYNLR

Download         Length: 375 bp

>T201851 NZ_CP098796:c89175-88894 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9515.81 Da        Isoelectric Point: 4.7330

>AT201851 WP_264385142.1 NZ_CP074352:64665-64907 [Siccibacter colletis]
MVMTAENIMGRILLDLPDEAIRRLDHLKQRRNTARAELLREAIEQYLERQTQNVLHEALGLWGEAAEDGLEYERKLREEW

Download         Length: 243 bp

>AT201851 NZ_CP098796:c89478-89176 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References