Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 39754..40787 Replicon chromosome
Accession NZ_CP074352
Organism Siccibacter colletis strain YSD YN2

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag KFZ77_RS00205 Protein ID WP_264385126.1
Coordinates 40212..40787 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag KFZ77_RS00200 Protein ID WP_031522196.1
Coordinates 39754..40212 (+) Length 153 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ77_RS00150 (KFZ77_00155) 34810..35064 + 255 WP_264385119.1 hypothetical protein -
KFZ77_RS00155 (KFZ77_00160) 35234..35458 + 225 WP_264385120.1 hypothetical protein -
KFZ77_RS00160 (KFZ77_00165) 35653..35895 + 243 WP_264385121.1 hypothetical protein -
KFZ77_RS00165 36004..36424 + 421 Protein_32 IS1-like element transposase -
KFZ77_RS00170 (KFZ77_00175) 36461..36718 + 258 WP_264385122.1 MafI family immunity protein -
KFZ77_RS00175 (KFZ77_00180) 37052..37294 + 243 WP_264385123.1 hypothetical protein -
KFZ77_RS00180 (KFZ77_00185) 37299..37451 + 153 WP_264385124.1 hypothetical protein -
KFZ77_RS00185 (KFZ77_00190) 37438..37677 + 240 WP_264385125.1 hypothetical protein -
KFZ77_RS00190 (KFZ77_00195) 37822..38565 - 744 WP_031522200.1 SDR family oxidoreductase -
KFZ77_RS00195 (KFZ77_00200) 38735..39670 + 936 WP_031522198.1 AraC family transcriptional regulator -
KFZ77_RS00200 (KFZ77_00205) 39754..40212 + 459 WP_031522196.1 helix-turn-helix domain-containing protein Antitoxin
KFZ77_RS00205 (KFZ77_00210) 40212..40787 + 576 WP_264385126.1 PIN domain-containing protein Toxin
KFZ77_RS00210 (KFZ77_00215) 40801..41331 - 531 WP_264385127.1 hypothetical protein -
KFZ77_RS00215 (KFZ77_00220) 41530..42579 - 1050 WP_264385128.1 NAD(P)-dependent alcohol dehydrogenase -
KFZ77_RS00220 (KFZ77_00225) 42613..43812 - 1200 WP_264385129.1 MFS transporter -
KFZ77_RS00225 (KFZ77_00230) 44093..44980 + 888 WP_031522187.1 LysR family transcriptional regulator -
KFZ77_RS00230 (KFZ77_00235) 45020..45478 - 459 WP_072002013.1 DUF943 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(83-129)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21537.02 Da        Isoelectric Point: 6.2271

>T201850 WP_264385126.1 NZ_CP074352:40212-40787 [Siccibacter colletis]
MEHSPYPVVLDACVLYPARLRDLLMHLGIAGLYQPKWSAEIHREWCRNLLMNRPDITQAALTRTVELMEKALPDARVVGF
ETLIEGLTLPDENDRHVLAVALRAKAEVIVTLNQKDFPASALQKFNIEALHPDDFITDLLDLSPGIALEAVRRQRQSLRH
PPLSIDDFLDMLLKQGLNGTVSVLKGYRQAI

Download         Length: 576 bp

>T201850 NZ_CP098796:c86927-86607 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 16992.35 Da        Isoelectric Point: 5.5679

>AT201850 WP_031522196.1 NZ_CP074352:39754-40212 [Siccibacter colletis]
MTTSLTALELPDARESELAQRGQQELAAFLSTKFETQRIAIVGDDNQTHTIELPARALSMLRDILGELAAGNAVQVVPIH
AELTTQEAANMLNVSRPHMVKLLEDGKLPFHKTGRHRRVLFADLMEYKQKREHESLEAMQALADQAQDTGMY

Download         Length: 459 bp

>AT201850 NZ_CP098796:c86614-86342 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References