Detailed information of TA system TA201846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3801692..3802391
• Replicon: chromosome
• Accession: NZ_CP074350
• Organism: Pantoea dispersa strain YSD_J2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KFZ74_RS17915
• Protein ID: WP_072208527.1
• Coordinates: 3802215..3802391 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KFZ74_RS17910
• Protein ID: WP_058757543.1
• Coordinates: 3801692..3802096 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFZ74_RS17895 (KFZ74_17865)	3798861..3799100	+	240	WP_238561247.1	hypothetical protein	-
KFZ74_RS17900 (KFZ74_17870)	3799195..3800634	-	1440	WP_058774923.1	PTS N-acetylmuramic acid transporter subunit IIBC	-
KFZ74_RS17905 (KFZ74_17875)	3800634..3801545	-	912	WP_058780882.1	N-acetylmuramic acid 6-phosphate etherase	-
KFZ74_RS17910 (KFZ74_17880)	3801692..3802096	-	405	WP_058757543.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KFZ74_RS17915 (KFZ74_17885)	3802215..3802391	-	177	WP_072208527.1	type II toxin-antitoxin system HicA family toxin	Toxin
KFZ74_RS17920 (KFZ74_17890)	3802566..3803867	-	1302	WP_021507820.1	glutamate/aspartate:proton symporter GltP	-
KFZ74_RS17925 (KFZ74_17895)	3804448..3806403	+	1956	WP_238561248.1	acetate--CoA ligase	-
KFZ74_RS17930 (KFZ74_17900)	3806577..3806906	+	330	WP_021313201.1	DUF485 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-55)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6824.11 Da
• Isoelectric Point: 10.6691

>T201846 WP_072208527.1 NZ_CP074350:c3802391-3802215 [Pantoea dispersa]
MSSRELIRMLLERGWILDRVKGSHHVFVRADKPYHISLPHPEKDLATGTLRKLLKMMD

Nucleotide

• Length: 177 bp

>T201846 NZ_CP098792:c89173-88892 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14655.39 Da
• Isoelectric Point: 4.9322

>AT201846 WP_058757543.1 NZ_CP074350:c3802096-3801692 [Pantoea dispersa]
MRFPVYLHKTENGSWSGFVPDVQGCFFAGNTVDEALSDAFGAIDAHVESLADAGKAIPKAASVETHINDEECQGGYWAFV
EIDLSRYEGKAVKLNITLPQNLLTKIDSHVEAHREYGSRSGFLAALARRELANI

Nucleotide

• Length: 405 bp

>AT201846 NZ_CP098792:c89476-89174 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA