201844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3190291..3190911 Replicon chromosome
Accession NZ_CP074350
Organism Pantoea dispersa strain YSD_J2

Toxin (Protein)


Gene name Hha Uniprot ID A0A246NIG6
Locus tag KFZ74_RS15140 Protein ID WP_021507203.1
Coordinates 3190693..3190911 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A246NI99
Locus tag KFZ74_RS15135 Protein ID WP_021313568.1
Coordinates 3190291..3190668 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ74_RS15105 (KFZ74_15065) 3186614..3186871 + 258 WP_021507208.1 type B 50S ribosomal protein L31 -
KFZ74_RS15110 (KFZ74_15070) 3186887..3187027 + 141 WP_010616859.1 type B 50S ribosomal protein L36 -
KFZ74_RS15115 (KFZ74_15075) 3187072..3187950 - 879 WP_058769397.1 metal ABC transporter substrate-binding protein -
KFZ74_RS15120 (KFZ74_15080) 3187972..3188811 - 840 WP_021507206.1 metal ABC transporter permease -
KFZ74_RS15125 (KFZ74_15085) 3188808..3189464 - 657 WP_021507205.1 ABC transporter ATP-binding protein -
KFZ74_RS15130 (KFZ74_15090) 3189792..3190145 + 354 WP_031279656.1 hypothetical protein -
KFZ74_RS15135 (KFZ74_15095) 3190291..3190668 + 378 WP_021313568.1 Hha toxicity modulator TomB Antitoxin
KFZ74_RS15140 (KFZ74_15100) 3190693..3190911 + 219 WP_021507203.1 HHA domain-containing protein Toxin
KFZ74_RS15150 (KFZ74_15110) 3191313..3191624 + 312 WP_021507202.1 MGMT family protein -
KFZ74_RS15155 (KFZ74_15115) 3191792..3192349 - 558 WP_211725174.1 YbaY family lipoprotein -
KFZ74_RS15160 (KFZ74_15120) 3192365..3192556 + 192 WP_146068777.1 hypothetical protein -
KFZ74_RS15165 (KFZ74_15125) 3192553..3193416 + 864 WP_211725173.1 acyl-CoA thioesterase II -
KFZ74_RS15170 (KFZ74_15130) 3193489..3194778 - 1290 WP_058775238.1 ammonium transporter AmtB -
KFZ74_RS15175 (KFZ74_15135) 3194812..3195150 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8538.87 Da        Isoelectric Point: 8.8662

>T201844 WP_021507203.1 NZ_CP074350:3190693-3190911 [Pantoea dispersa]
MSNPALTKTDYLMRLRRCRSIDTLERVIEKNKYELPDDELAVFYSAADHRLAELTMNKLYDKVPGSVWKYVR

Download         Length: 219 bp

>T201844 NZ_CP098791:c3670594-3670205 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14665.34 Da        Isoelectric Point: 4.4796

>AT201844 WP_021313568.1 NZ_CP074350:3190291-3190668 [Pantoea dispersa]
MDEYSPKRHDIAQLKFLCENLFDESMATLTDSHHGWVNDPTSPGNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSSYGINTQDLQRWQRSAKRLFNLFAEECAYLQQPSHSF

Download         Length: 378 bp

>AT201844 NZ_CP098791:c3670858-3670601 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246NIG6

Antitoxin

Source ID Structure
AlphaFold DB A0A246NI99

References