Detailed information of TA system TA201843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2594670..2595284
• Replicon: chromosome
• Accession: NZ_CP074350
• Organism: Pantoea dispersa strain YSD_J2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A246NCD7
• Locus tag: KFZ74_RS12220
• Protein ID: WP_058757609.1
• Coordinates: 2594670..2594852 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KFZ74_RS12225
• Protein ID: WP_022548759.1
• Coordinates: 2594892..2595284 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFZ74_RS12165 (KFZ74_12125)	2589815..2590477	+	663	WP_021506360.1	MBL fold metallo-hydrolase	-
KFZ74_RS12170 (KFZ74_12130)	2590478..2590891	-	414	WP_058757613.1	GNAT family N-acetyltransferase	-
KFZ74_RS12175 (KFZ74_12135)	2590913..2591296	-	384	WP_058757612.1	hypothetical protein	-
KFZ74_RS12180 (KFZ74_12140)	2591514..2591870	+	357	WP_010617204.1	DUF4186 domain-containing protein	-
KFZ74_RS12185 (KFZ74_12145)	2591889..2592068	-	180	WP_031279245.1	hypothetical protein	-
KFZ74_RS12190 (KFZ74_12150)	2592272..2592601	+	330	WP_021506365.1	hypothetical protein	-
KFZ74_RS12195 (KFZ74_12155)	2592663..2593211	+	549	WP_238560976.1	hypothetical protein	-
KFZ74_RS12200 (KFZ74_12160)	2593236..2593442	-	207	WP_021506367.1	DUF2767 family protein	-
KFZ74_RS12205 (KFZ74_12165)	2593623..2593871	+	249	WP_021506368.1	DUF883 family protein	-
KFZ74_RS12210 (KFZ74_12170)	2593906..2594103	-	198	WP_150058304.1	hypothetical protein	-
KFZ74_RS12215 (KFZ74_12175)	2594204..2594401	-	198	WP_021506369.1	DUF6404 family protein	-
KFZ74_RS12220 (KFZ74_12180)	2594670..2594852	+	183	WP_058757609.1	type II toxin-antitoxin system HicA family toxin	Toxin
KFZ74_RS12225 (KFZ74_12185)	2594892..2595284	+	393	WP_022548759.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KFZ74_RS12230 (KFZ74_12190)	2595369..2596625	+	1257	WP_058757608.1	mechanosensitive ion channel	-
KFZ74_RS12235 (KFZ74_12195)	2596748..2597998	-	1251	WP_010617214.1	NADP-dependent isocitrate dehydrogenase	-
KFZ74_RS12240 (KFZ74_12200)	2598100..2598768	+	669	WP_238560977.1	23S rRNA pseudouridine(2457) synthase RluE	-
KFZ74_RS12245 (KFZ74_12205)	2598813..2599286	+	474	WP_238560978.1	NUDIX hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-124)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6958.19 Da
• Isoelectric Point: 10.9062

>T201843 WP_058757609.1 NZ_CP074350:2594670-2594852 [Pantoea dispersa]
MKSATLIKLLQKNGWKLERIRGSHHQFSHPDFAHLITVPHPQKDMKTGTLMQILKDARLD

Nucleotide

• Length: 183 bp

>T201843 NZ_CP098779:c215937-215650 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14554.49 Da
• Isoelectric Point: 4.8732

>AT201843 WP_022548759.1 NZ_CP074350:2594892-2595284 [Pantoea dispersa]
MLFPALVEIDADGSASGYFPDVTGCYFAGDTPEQTLQDAQSALHAHFELMAEKGLLIPEPAQHWQQEFSQPGVWIYVDID
VTRYLGKSERINITMPHLLIEKIDKMVSNNARYSSRSHFLAEAARKALVS

Nucleotide

• Length: 393 bp

>AT201843 NZ_CP098779:c216176-215937 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A246NCD7