201842

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1960391..1961023 Replicon chromosome
Accession NZ_CP074350
Organism Pantoea dispersa strain YSD_J2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KFZ74_RS09085 Protein ID WP_238561920.1
Coordinates 1960391..1960567 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KFZ74_RS09090 Protein ID WP_238561921.1
Coordinates 1960616..1961023 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ74_RS09050 (KFZ74_09025) 1955800..1956210 + 411 WP_238561915.1 MarR family transcriptional regulator -
KFZ74_RS23465 1956207..1956329 + 123 WP_274526770.1 hypothetical protein -
KFZ74_RS09055 (KFZ74_09030) 1956326..1957156 + 831 WP_238561916.1 DNA-binding protein -
KFZ74_RS09060 (KFZ74_09035) 1957212..1957583 + 372 WP_238561917.1 RusA family crossover junction endodeoxyribonuclease -
KFZ74_RS09065 (KFZ74_09040) 1957711..1958505 + 795 WP_238562024.1 KilA-N domain-containing protein -
KFZ74_RS09070 (KFZ74_09045) 1958513..1959529 + 1017 WP_238561918.1 DUF968 domain-containing protein -
KFZ74_RS09075 (KFZ74_09050) 1959550..1959981 + 432 WP_238561919.1 antiterminator Q family protein -
KFZ74_RS09085 (KFZ74_09060) 1960391..1960567 + 177 WP_238561920.1 type II toxin-antitoxin system HicA family toxin Toxin
KFZ74_RS09090 (KFZ74_09065) 1960616..1961023 + 408 WP_238561921.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KFZ74_RS09095 (KFZ74_09070) 1961286..1961639 + 354 WP_238561922.1 class II holin family protein -
KFZ74_RS09100 (KFZ74_09075) 1961639..1962178 + 540 WP_238561923.1 lysozyme -
KFZ74_RS09105 (KFZ74_09080) 1962217..1962552 + 336 WP_238562025.1 hypothetical protein -
KFZ74_RS09110 (KFZ74_09085) 1962931..1963545 + 615 WP_238561924.1 hypothetical protein -
KFZ74_RS09115 (KFZ74_09090) 1963563..1963967 + 405 WP_238561925.1 hypothetical protein -
KFZ74_RS09120 (KFZ74_09095) 1964146..1964391 + 246 WP_238561926.1 hypothetical protein -
KFZ74_RS09125 (KFZ74_09100) 1964546..1964755 + 210 WP_238561927.1 hypothetical protein -
KFZ74_RS09130 (KFZ74_09105) 1964807..1965241 + 435 WP_238561928.1 hypothetical protein -
KFZ74_RS09135 (KFZ74_09110) 1965303..1965551 + 249 WP_238561929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1947237..1989073 41836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-131)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6725.83 Da        Isoelectric Point: 11.4032

>T201842 WP_238561920.1 NZ_CP074350:1960391-1960567 [Pantoea dispersa]
VKQSEFRRWLESQGVEVSNGTNHLKLRYNGKRSVMPRHPGSELKEPLRKAIIKQLGLK

Download         Length: 177 bp

>T201842 NZ_CP098779:93347-94672 [Enterobacter hormaechei]
ATGAGCCGGAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTAGA
CAGCTTACAATACCTTCCTGACTGGAGTGCAGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTTCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACAGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGCGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAAACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCATTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAGTTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14701.85 Da        Isoelectric Point: 4.1590

>AT201842 WP_238561921.1 NZ_CP074350:1960616-1961023 [Pantoea dispersa]
MRYPINLEPCDGGYVVSFPDIPEALTQGDTLEEAMAMGLDALVTAFEFYFEDGNKVPEPSEVAGDYVEVPASVVAKVLML
SAFIDSGLTQVELASRMGVKKQEVTRLFDLQHATKIDTIQKALSALGRRLEMTAA

Download         Length: 408 bp

>AT201842 NZ_CP098779:93049-93342 [Enterobacter hormaechei]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGGGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCTATCCTGGGCGTAAAAATCAGCTTCTCCTCGACAACCGCCTCTTCAGAGGGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References