Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 518413..518984 Replicon chromosome
Accession NZ_CP074347
Organism Serratia entomophila strain 626

Toxin (Protein)


Gene name relE Uniprot ID A0A6M5HME0
Locus tag KFQ06_RS02415 Protein ID WP_061799809.1
Coordinates 518709..518984 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag KFQ06_RS02410 Protein ID WP_013811307.1
Coordinates 518413..518700 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ06_RS02385 (KFQ06_02395) 514180..515265 - 1086 WP_252961313.1 carbon-phosphorus lyase complex subunit PhnI -
KFQ06_RS02390 (KFQ06_02400) 515265..515846 - 582 WP_234588036.1 phosphonate C-P lyase system protein PhnH -
KFQ06_RS02395 (KFQ06_02405) 515849..516292 - 444 WP_252961314.1 phosphonate C-P lyase system protein PhnG -
KFQ06_RS02400 (KFQ06_02410) 516293..517021 - 729 WP_234588040.1 phosphonate metabolism transcriptional regulator PhnF -
KFQ06_RS02405 (KFQ06_02415) 517249..518307 + 1059 WP_252961939.1 permease -
KFQ06_RS02410 (KFQ06_02420) 518413..518700 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFQ06_RS02415 (KFQ06_02425) 518709..518984 + 276 WP_061799809.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
KFQ06_RS02420 (KFQ06_02430) 518990..519454 - 465 WP_252961315.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KFQ06_RS02425 (KFQ06_02435) 519623..521761 - 2139 WP_252961316.1 anaerobic ribonucleoside-triphosphate reductase -
KFQ06_RS02430 (KFQ06_02440) 521967..522881 - 915 WP_234588052.1 LysR family transcriptional regulator -
KFQ06_RS02435 (KFQ06_02445) 522986..523510 + 525 WP_252961317.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10766.50 Da        Isoelectric Point: 8.4940

>T201821 WP_061799809.1 NZ_CP074347:518709-518984 [Serratia entomophila]
MRIEWDNAALRDRERIFEFLYIFNPQAAEQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T201821 NZ_CP098777:2049319-2049597 [Cronobacter sakazakii]
ATGATCAGAAGCTTCAGGCATAAAGGCCTGCAACGCTATTTCGAAACGGGTTCCACCGCAGGCATTCATGCCCTCCATGC
CAGAAAGATTTCTCTGCGGCTGGCGGTGCTGAATCAGGCGATAAGACCCGCTGACGTCGACTTACCGGGATTTTTCCTGC
ATCCCCTGACGGGGGATCGTAAAGGTATATGGGCTGTGACCGTCAGCGGAAACTGGCGCATCACGTTTGAGTTTCGGGAT
GGCGATGTCTTTATCGTCAACTATGAGGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT201821 WP_013811307.1 NZ_CP074347:518413-518700 [Serratia entomophila]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT201821 NZ_CP098777:2049597-2049884 [Cronobacter sakazakii]
ATGGCAACGATGTTTAACCCACCGCACCCGGGCAGGCTGGTGCAGGAGTCAATGGAAGCGCTCGGCCTCAGTGCCCGTGC
GCTGGCCAAAGCGCTGGACGTCGCGCCGTCGACGGTGCAGCGTCTGCTGGTCGGCAAATCTGACGTCTCCCCGGAAATGG
CGCTGCGTCTCTCGGCAGTCCTTGGCAGCTCGCCGCATGTCTGGCTGGGTATGCAGAATGAATACGATCTCTTTCAGGCG
CGCCAGTCTGTTGATTTCTCGCACCTGCAACGGTTGCAGAGGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5HME0

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References