Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1369488..1370265 Replicon chromosome
Accession NZ_CP074346
Organism Pasteurella atlantica strain NVI-9100

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag KGI96_RS06435 Protein ID WP_211599247.1
Coordinates 1369765..1370265 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID -
Locus tag KGI96_RS06430 Protein ID WP_211599246.1
Coordinates 1369488..1369772 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGI96_RS06410 (KGI96_06410) 1364962..1365639 - 678 WP_211599242.1 methionine ABC transporter permease -
KGI96_RS06415 (KGI96_06415) 1365629..1366663 - 1035 WP_211599243.1 methionine ABC transporter ATP-binding protein MetN -
KGI96_RS06420 (KGI96_06420) 1366839..1368662 + 1824 WP_211599244.1 ATP-binding protein -
KGI96_RS06425 (KGI96_06425) 1368848..1369135 - 288 WP_211599245.1 50S ribosomal protein L25 -
KGI96_RS06430 (KGI96_06430) 1369488..1369772 + 285 WP_211599246.1 DUF1778 domain-containing protein Antitoxin
KGI96_RS06435 (KGI96_06435) 1369765..1370265 + 501 WP_211599247.1 N-acetyltransferase Toxin
KGI96_RS06440 (KGI96_06440) 1370390..1370668 + 279 WP_211599248.1 hypothetical protein -
KGI96_RS06445 (KGI96_06445) 1370706..1370870 + 165 WP_211599249.1 hypothetical protein -
KGI96_RS06455 (KGI96_06455) 1371347..1372165 - 819 Protein_1262 site-specific integrase -
KGI96_RS06460 (KGI96_06460) 1372259..1374202 - 1944 WP_211599250.1 MobH family relaxase -
KGI96_RS06465 (KGI96_06465) 1374584..1374883 - 300 WP_229577136.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-90)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18651.68 Da        Isoelectric Point: 9.4848

>T201820 WP_211599247.1 NZ_CP074346:1369765-1370265 [Pasteurella atlantica]
MPKYIEEPLDKAHNRKNFDCGNEELNTFLRCYAGQSHKKGTAKTYLTLDKETKKIIGFYSITLTSIEYNQIPKSFQKGLS
RHQVPLFILARLGVDVSEQNKGIGGVLLYKAIERCIKVSEEVGGIGLLIEAKDDDVAKWYSKFGAISLPDKPLSLILPFS
TIKNIK

Download         Length: 501 bp

>T201820 NZ_CP098777:1763925-1764221 [Cronobacter sakazakii]
ATGCAGAAGCATATCGGCAGTTTTCGTGACGCCTGGCTGGCGGCGTTTTTCGTGTATTCGACGCCACACCGCAACATCCC
GGCGGAGATTCATACCACACTGGCGCGCAAGCTCGACATCATCAACGCAGCAACGTCATACCGCGATCTTCGCTCGCCGC
CTGGCAACCGCTTTGAGGCGCTGAGCGGTAAATTGCAGGGGTATTCATCGATTCGGGTCAACCATCACTACCGCCTGATT
TTCAGATGGGTGGAAGGCAAAGCGGAAGATCTCTATTTAGATCCGCATGATTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10645.20 Da        Isoelectric Point: 6.4694

>AT201820 WP_211599246.1 NZ_CP074346:1369488-1369772 [Pasteurella atlantica]
MARAINTTSDRISIRISRDDKEILQKATLLSKTTITDFVLKHVLYNAKEIVKEHEESSLSKNDLAFIMDLLDNPPAPNER
LMKAAKTAQDLYDA

Download         Length: 285 bp

>AT201820 NZ_CP098777:1764254-1764595 [Cronobacter sakazakii]
ATGAAACAGGCAACCAGAAAGCCCACGACGCCCGGCGAGATCCTGGTGTACGAATACCTGGAGCCGCTCGGCCTTAAAAT
TAACGAGGTGGCGGAGATGCTTTGCGTCCATCGTAATAGCGTGAGCGCGCTGGTGAACAATAACCGCAAACTCACTACAG
ATATGGCGTTTCGTCTGGCAAAAGCGTTTGGAACCTCAGTTGATTTCTGGCTTAACCTGCAGGCGGCTGTCGATCTGTGG
GAGGTCGAGAATGATATGCGCATTCAGGAAGCGTTCAGCCGCATCGTACCCGCTGCGGAGTTTATCGCCCGGCGCGACGC
GCAGAAGAAAGCTGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References