Detailed information of TA system TA201819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 1295486..1295988
• Replicon: chromosome
• Accession: NZ_CP074346
• Organism: Pasteurella atlantica strain NVI-9100

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KGI96_RS06105
• Protein ID: WP_211598264.1
• Coordinates: 1295486..1295740 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KGI96_RS06110
• Protein ID: WP_211598266.1
• Coordinates: 1295737..1295988 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGI96_RS06080 (KGI96_06080)	1290939..1291853	-	915	WP_211598253.1	glycosyltransferase family 8 protein	-
KGI96_RS06085 (KGI96_06085)	1291863..1292633	-	771	WP_211598256.1	glycosyltransferase family 25 protein	-
KGI96_RS06090 (KGI96_06090)	1292847..1293893	-	1047	WP_211598258.1	extracellular solute-binding protein	-
KGI96_RS06095 (KGI96_06095)	1294056..1294772	+	717	WP_211598260.1	DnaA regulatory inactivator Hda	-
KGI96_RS06100 (KGI96_06100)	1294774..1295466	-	693	WP_211598262.1	16S rRNA pseudouridine(516) synthase RsuA	-
KGI96_RS06105 (KGI96_06105)	1295486..1295740	-	255	WP_211598264.1	Txe/YoeB family addiction module toxin	Toxin
KGI96_RS06110 (KGI96_06110)	1295737..1295988	-	252	WP_211598266.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
KGI96_RS06115 (KGI96_06115)	1296112..1296825	-	714	WP_211598268.1	hypothetical protein	-
KGI96_RS06120 (KGI96_06120)	1296845..1297555	-	711	WP_211598270.1	bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG	-
KGI96_RS06125 (KGI96_06125)	1297653..1298291	-	639	WP_211598273.1	DUF2057 domain-containing protein	-
KGI96_RS06130 (KGI96_06130)	1298436..1299323	+	888	WP_211598275.1	CNNM family magnesium/cobalt transport protein CorC	-
KGI96_RS06135 (KGI96_06135)	1299326..1300852	+	1527	WP_213156391.1	apolipoprotein N-acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10092.68 Da
• Isoelectric Point: 9.7073

>T201819 WP_211598264.1 NZ_CP074346:c1295740-1295486 [Pasteurella atlantica]
MIVCFTDKGWEDYLYWQETDKKTLKRINSLIKEIKRSPFIGKGKPEPLKHSLSGFWSRRITEEHRLVYRVSEDALSIVAC
RYHY

Nucleotide

• Length: 255 bp

>T201819 NZ_CP098777:c1094753-1094535 [Cronobacter sakazakii]
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTGAGACGTTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTATCCGACAACGAACTGGCGGTATTTTATTCAGCGGCGGATCATCGTCTGGCTGAAC
TGACGATGAATAAACTCTACGATAAAATTCCGACCGCCGTGTGGAAGTTCGTTCGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9428.74 Da
• Isoelectric Point: 4.4693

>AT201819 WP_211598266.1 NZ_CP074346:c1295988-1295737 [Pasteurella atlantica]
MQVMTYTEARQNLAQTMTATAENCEPVLITRSNNESCVLISLREYEALEETAYLLRSPANAKHLLESIEELKLGNVTKRE
LIE

Nucleotide

• Length: 252 bp

>AT201819 NZ_CP098777:c1095154-1094780 [Cronobacter sakazakii]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTTGC
CACGCTCGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACTTCCGCCGTTAACCTGCAACTCAACGACTTGATTGAGC
ATATTGCCAGCTTCGGCCTGAATTATAAAATTAAGCATGAAGATGACGCAGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACCTTTATGCTGTTCAGCAATTACGGTATCAATGCGCAAGATTTACAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTTGTAAACGCCAGCAAAGAAAACCCTGTAAGCTTGTCTTTTTAA