Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 3408788..3409514 | Replicon | chromosome |
| Accession | NZ_CP074233 | ||
| Organism | Salmonella bongori CFSAN000510 strain SGSC 3100 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | A0A248KBV8 |
| Locus tag | JYN33_RS16180 | Protein ID | WP_001194750.1 |
| Coordinates | 3408788..3409129 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A248KCL1 |
| Locus tag | JYN33_RS16185 | Protein ID | WP_000380487.1 |
| Coordinates | 3409173..3409514 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JYN33_RS21180 (3404069) | 3404069..3404333 | + | 265 | Protein_3179 | IS3 family transposase | - |
| JYN33_RS16160 (3404668) | 3404668..3405987 | + | 1320 | WP_001218450.1 | site-specific integrase | - |
| JYN33_RS16165 (3406025) | 3406025..3407077 | - | 1053 | WP_000575274.1 | macro domain-containing protein | - |
| JYN33_RS16170 (3407091) | 3407091..3407738 | - | 648 | WP_000026701.1 | DUF4433 domain-containing protein | - |
| JYN33_RS16175 (3407839) | 3407839..3408672 | - | 834 | WP_001192753.1 | DUF4942 domain-containing protein | - |
| JYN33_RS16180 (3408788) | 3408788..3409129 | - | 342 | WP_001194750.1 | TA system toxin CbtA family protein | Toxin |
| JYN33_RS16185 (3409173) | 3409173..3409514 | - | 342 | WP_000380487.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JYN33_RS16190 (3409537) | 3409537..3409758 | - | 222 | WP_000691988.1 | DUF987 family protein | - |
| JYN33_RS16195 (3409755) | 3409755..3410255 | - | 501 | WP_001090292.1 | DNA repair protein RadC | - |
| JYN33_RS16200 (3410268) | 3410268..3411086 | - | 819 | WP_001234407.1 | DUF932 domain-containing protein | - |
| JYN33_RS16205 (3411188) | 3411188..3411433 | - | 246 | WP_000082136.1 | DUF905 domain-containing protein | - |
| JYN33_RS16210 (3411508) | 3411508..3412422 | - | 915 | WP_000797249.1 | hypothetical protein | - |
| JYN33_RS16215 (3412487) | 3412487..3412690 | - | 204 | WP_000508162.1 | hypothetical protein | - |
| JYN33_RS16220 (3412707) | 3412707..3412853 | - | 147 | WP_023892166.1 | hypothetical protein | - |
| JYN33_RS16225 (3412926) | 3412926..3413640 | - | 715 | Protein_3193 | WYL domain-containing protein | - |
| JYN33_RS16230 (3413993) | 3413993..3414298 | - | 306 | WP_000227087.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3384193..3427148 | 42955 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13116.01 Da Isoelectric Point: 9.7617
>T201817 WP_001194750.1 NZ_CP074233:c3409129-3408788 [Salmonella bongori CFSAN000510]
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH
Download Length: 342 bp
>T201817 NZ_CP098774:c2392064-2391771 [Sphingomonas sp. QA11]
ATGAGGATCAAGTGGACCAGCAAGGCGTCGTCGGACCTTGTGCGCCTGCACGAGCATCTGCAGCCGGTCGCGCCCGATGC
GGCGGCACGGGTCGTCCAGCAGCTTGCGCGCGCGCCCGACCGGCTCCTCGACTATCCGCGGATCGGCGAGAAGCTGGAAG
CCTATGAGCCGCGCGAGGTCCGGCGGATCATCGTGGGCAATTACGAGCTGCGGTATGAGATAGCCGACGCCACGATCTTC
ATCCTGCGTCTCTGGCACGCTCGCGAGAACCGCAGCTTCAAGTCGGAGGAGTAG
ATGAGGATCAAGTGGACCAGCAAGGCGTCGTCGGACCTTGTGCGCCTGCACGAGCATCTGCAGCCGGTCGCGCCCGATGC
GGCGGCACGGGTCGTCCAGCAGCTTGCGCGCGCGCCCGACCGGCTCCTCGACTATCCGCGGATCGGCGAGAAGCTGGAAG
CCTATGAGCCGCGCGAGGTCCGGCGGATCATCGTGGGCAATTACGAGCTGCGGTATGAGATAGCCGACGCCACGATCTTC
ATCCTGCGTCTCTGGCACGCTCGCGAGAACCGCAGCTTCAAGTCGGAGGAGTAG
Antitoxin
Download Length: 114 a.a. Molecular weight: 12770.65 Da Isoelectric Point: 9.4771
>AT201817 WP_000380487.1 NZ_CP074233:c3409514-3409173 [Salmonella bongori CFSAN000510]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNIVFPMFIKRMEVALRTGALNPREAR
RFTTALRGIICEADTRGSFGYVYLSLYPTVVKN
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNIVFPMFIKRMEVALRTGALNPREAR
RFTTALRGIICEADTRGSFGYVYLSLYPTVVKN
Download Length: 342 bp
>AT201817 NZ_CP098774:c2392330-2392061 [Sphingomonas sp. QA11]
ATGGCCACTGATACCAAAGTGCTGACCGCCCATGTGCCACTCGGACTTGCTGAAAAGGTCGAAGCGATGGCGGCGCGGCT
CGAACGCTCGCGCGGCTGGGTGATGAAGCAAGCGCTGGCCGCCTGGGTCGATCAAGAGGAGGAGCGTCACCAGATGACGC
TCGAAGCGCTGGACGATGTGGATGCCGGGCGGGTGATCGACCATCACGCCGTCCAAGCATGGGCGGACAGCCTCGGAACC
GACAAGCCGCTTCCGCCGCCAACCGCATGA
ATGGCCACTGATACCAAAGTGCTGACCGCCCATGTGCCACTCGGACTTGCTGAAAAGGTCGAAGCGATGGCGGCGCGGCT
CGAACGCTCGCGCGGCTGGGTGATGAAGCAAGCGCTGGCCGCCTGGGTCGATCAAGAGGAGGAGCGTCACCAGATGACGC
TCGAAGCGCTGGACGATGTGGATGCCGGGCGGGTGATCGACCATCACGCCGTCCAAGCATGGGCGGACAGCCTCGGAACC
GACAAGCCGCTTCCGCCGCCAACCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A248KBV8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A248KCL1 |