Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3254117..3254737 Replicon chromosome
Accession NZ_CP074233
Organism Salmonella bongori CFSAN000510 strain SGSC 3100

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JYN33_RS15485 Protein ID WP_001280991.1
Coordinates 3254519..3254737 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JYN33_RS15480 Protein ID WP_000344807.1
Coordinates 3254117..3254491 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYN33_RS15470 (3249256) 3249256..3250449 + 1194 WP_001039205.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JYN33_RS15475 (3250472) 3250472..3253621 + 3150 WP_001132513.1 efflux RND transporter permease AcrB -
JYN33_RS15480 (3254117) 3254117..3254491 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JYN33_RS15485 (3254519) 3254519..3254737 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JYN33_RS15490 (3254916) 3254916..3255467 + 552 WP_001278796.1 maltose O-acetyltransferase -
JYN33_RS15495 (3255585) 3255585..3256055 + 471 WP_000136180.1 YlaC family protein -
JYN33_RS15500 (3256108) 3256108..3256248 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JYN33_RS15505 (3256254) 3256254..3256514 - 261 WP_000801419.1 type B 50S ribosomal protein L31 -
JYN33_RS15510 (3256719) 3256719..3258269 + 1551 WP_000213124.1 EAL domain-containing protein -
JYN33_RS15520 (3258508) 3258508..3258897 + 390 WP_000908589.1 MGMT family protein -
JYN33_RS15525 (3258930) 3258930..3259499 - 570 WP_000779806.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T201816 WP_001280991.1 NZ_CP074233:3254519-3254737 [Salmonella bongori CFSAN000510]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T201816 NZ_CP098772:c4692011-4691694 [Alteromonas macleodii]
ATGGTAATTATTGAAACACCTATATTCACCAAGCTCATAAAAGAGCTGATGAATGATGATGAATACAAAGACTTGCAGGA
AGCACTTGTTAGCAGGCCAGATAGAGGCTCATTAATTAAAAATAGTGGTGGCCTTAGAAAGGTACGCTGGGTGCTGGCAG
GAAGGGGTAAAAGTGGTGGAGCTAGAGTTATCTATTATTGGATGACCGACAACGACCAACTTTATATGTTGTTGGCATAC
CCAAAAAATGTGCAGGATAATTTGACAGATACGCAGCTTAAAACGCTGAAGAAGATCGTAGAGAGGTGGTCAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT201816 WP_000344807.1 NZ_CP074233:3254117-3254491 [Salmonella bongori CFSAN000510]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT201816 NZ_CP098772:c4691697-4691407 [Alteromonas macleodii]
ATGAATGATGACATGTTTGAACAATTGATAGAGAGTGTGTCTCAGGCAGACGATATCATCAAAGGTAAGGCAAAGCCTTC
CCGTACAACTGAATTTGCTGAGCCTCAAGTAAAAGCCATTCGCGCAAAAACGGGGTTAACACAAACCCGTTTTGCTGACG
TTTTGGGGGTGAGCAAACGCACACTAGAGAATTGGGAACAAGGCCGACGCCATCCAACAGGTCCTGCTCGTGCTTTGCTT
AAGATCTTAGATGCTGATCCTAAGCACGCCTTGGAAGCACTTAATCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References