Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2226979..2227721 Replicon chromosome
Accession NZ_CP074233
Organism Salmonella bongori CFSAN000510 strain SGSC 3100

Toxin (Protein)


Gene name tacT Uniprot ID A0A248K916
Locus tag JYN33_RS10575 Protein ID WP_000521216.1
Coordinates 2227233..2227721 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID S5MPV7
Locus tag JYN33_RS10570 Protein ID WP_020844238.1
Coordinates 2226979..2227245 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYN33_RS10560 (2222218) 2222218..2224746 + 2529 WP_000613169.1 malto-oligosyltrehalose synthase -
JYN33_RS10565 (2224789) 2224789..2226864 + 2076 WP_000210608.1 glycogen debranching protein GlgX -
JYN33_RS10570 (2226979) 2226979..2227245 + 267 WP_020844238.1 DUF1778 domain-containing protein Antitoxin
JYN33_RS10575 (2227233) 2227233..2227721 + 489 WP_000521216.1 GNAT family N-acetyltransferase Toxin
JYN33_RS10580 (2228279) 2228279..2228668 + 390 WP_015702869.1 RidA family protein -
JYN33_RS10585 (2228736) 2228736..2229815 - 1080 WP_000954703.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
JYN33_RS10590 (2229992) 2229992..2230480 - 489 WP_001293644.1 MarR family winged helix-turn-helix transcriptional regulator -
JYN33_RS10595 (2230525) 2230525..2232033 + 1509 WP_000196705.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-151)

Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17719.47 Da        Isoelectric Point: 9.5852

>T201815 WP_000521216.1 NZ_CP074233:2227233-2227721 [Salmonella bongori CFSAN000510]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEATGGLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Download         Length: 489 bp

>T201815 NZ_CP098772:c3095539-3095222 [Alteromonas macleodii]
ATGGCACAGTTTGATGTTTACAGAAACCCAAGCTCAAAAACAAATAAAGCTTACCCCTTTCTTGTAGATGTTCAAAACTC
TGTAATTGACCAATTAGCAACAAGGTTAGTTGTACCGCTGACGAAGAATGAGACTAAAAATAGTCTTTATATGAGAAGCC
TTACGCCGAAGATAGAACTCGAAGGCGAGACATACCTATTCCTGACTCAACAACTTAGTTCCATACCCGAAGATGTGCTC
AAGGACTGCATCGGTTCTTTAGCGCAATCCCGCGAATTGCTAATAGGTGCATTAGACTTTGCTATTACTGGAATATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9999.47 Da        Isoelectric Point: 4.7961

>AT201815 WP_020844238.1 NZ_CP074233:2226979-2227245 [Salmonella bongori CFSAN000510]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Download         Length: 267 bp

>AT201815 NZ_CP098772:c3095784-3095539 [Alteromonas macleodii]
ATGCAAGATTTATATGACATTAATGCCCCAAAAAAAGCGACTAATTTGAGCTTAAACAGCGACTTATTACAAAAAGCTAG
AGACTTAAAAGTTAACCTGTCTGCAACCTTAGAACAGGCACTTAAAGACAAGTTGAAAAGTGTTGAAGAAGAAAGGTGGA
AAAAAGAAAACAAAGCTGCAATAGCTGCGTACAACGAGTTTGTTGCTGAGAACGGCTGTATAGGTGATGAGTACAGGAAT
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248K916

Antitoxin

Source ID Structure
AlphaFold DB S5MPV7

References