Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 827824..828484 Replicon chromosome
Accession NZ_CP074233
Organism Salmonella bongori CFSAN000510 strain SGSC 3100

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag JYN33_RS04035 Protein ID WP_000244759.1
Coordinates 828071..828484 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag JYN33_RS04030 Protein ID WP_000351186.1
Coordinates 827824..828090 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYN33_RS04010 (823821) 823821..825254 - 1434 WP_000737109.1 6-phospho-beta-glucosidase -
JYN33_RS04015 (825412) 825412..825723 + 312 WP_015702996.1 N(4)-acetylcytidine aminohydrolase -
JYN33_RS04020 (825887) 825887..826546 + 660 WP_024135108.1 hemolysin III family protein -
JYN33_RS04025 (826597) 826597..827577 - 981 WP_000896119.1 tRNA-modifying protein YgfZ -
JYN33_RS04030 (827824) 827824..828090 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
JYN33_RS04035 (828071) 828071..828484 + 414 WP_000244759.1 protein YgfX Toxin
JYN33_RS04040 (828536) 828536..829057 - 522 WP_001055887.1 flavodoxin FldB -
JYN33_RS04045 (829170) 829170..830066 + 897 WP_000806655.1 site-specific tyrosine recombinase XerD -
JYN33_RS04050 (830090) 830090..830803 + 714 WP_000745612.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JYN33_RS04055 (830809) 830809..832542 + 1734 WP_000813377.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T201806 WP_000244759.1 NZ_CP074233:828071-828484 [Salmonella bongori CFSAN000510]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T201806 NZ_CP098770:741800-742285 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT201806 WP_000351186.1 NZ_CP074233:827824-828090 [Salmonella bongori CFSAN000510]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201806 NZ_CP098770:741510-741803 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References