Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-paaA/-
Location 1802270..1802717 Replicon chromosome
Accession NZ_CP074200
Organism Halomonas sp. FeN2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KF947_RS08350 Protein ID WP_227405948.1
Coordinates 1802270..1802545 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag KF947_RS08355 Protein ID WP_223288456.1
Coordinates 1802532..1802717 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF947_RS08335 (KF947_08325) 1798536..1799798 + 1263 WP_227405945.1 D-amino acid dehydrogenase -
KF947_RS08340 (KF947_08330) 1800203..1801477 + 1275 WP_227405946.1 TRAP transporter large permease -
KF947_RS08345 (KF947_08335) 1801501..1802262 + 762 WP_227405947.1 M15 family metallopeptidase -
KF947_RS08350 (KF947_08340) 1802270..1802545 - 276 WP_227405948.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF947_RS08355 (KF947_08345) 1802532..1802717 - 186 WP_223288456.1 stability determinant Antitoxin
KF947_RS08360 (KF947_08350) 1802833..1803600 - 768 WP_227405949.1 amino acid ABC transporter ATP-binding protein -
KF947_RS08365 (KF947_08355) 1803593..1804258 - 666 WP_227405950.1 amino acid ABC transporter permease -
KF947_RS08370 (KF947_08360) 1804281..1804922 - 642 WP_022521643.1 amino acid ABC transporter permease -
KF947_RS08375 (KF947_08365) 1804988..1805845 - 858 WP_227405951.1 transporter substrate-binding domain-containing protein -
KF947_RS08380 (KF947_08370) 1806116..1807645 + 1530 WP_227405952.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10521.07 Da        Isoelectric Point: 6.2125

>T201803 WP_227405948.1 NZ_CP074200:c1802545-1802270 [Halomonas sp. FeN2]
MLLVEWRPQARESLWAILDYLSQRNPYAAEALYQAIEEATEALPQHPYLYRPGRVVGTREAVVHPNYIVVYRLAAGCIEI
VNVLHARQEYP

Download         Length: 276 bp

>T201803 NZ_CP098769:c5288842-5288459 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 7089.86 Da        Isoelectric Point: 4.3707

>AT201803 WP_223288456.1 NZ_CP074200:c1802717-1802532 [Halomonas sp. FeN2]
MGTPLDPIISEFETQEQADSYQRWFRERVQASLDDPRPSIPHDDVMGEMRELIAKRRDAAS

Download         Length: 186 bp

>AT201803 NZ_CP098769:c5289084-5288842 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References