Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 895480..895993 Replicon chromosome
Accession NZ_CP074200
Organism Halomonas sp. FeN2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag KF947_RS04220 Protein ID WP_227405533.1
Coordinates 895730..895993 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KF947_RS04215 Protein ID WP_133730114.1
Coordinates 895480..895740 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF947_RS04185 (KF947_04185) 890853..891173 - 321 WP_227405528.1 hypothetical protein -
KF947_RS04190 (KF947_04190) 891267..891506 - 240 WP_227406275.1 HigA family addiction module antitoxin -
KF947_RS04195 (KF947_04195) 891594..892214 - 621 WP_227405529.1 LysE family translocator -
KF947_RS04200 (KF947_04200) 892385..893224 - 840 WP_227405530.1 tryptophan synthase subunit alpha -
KF947_RS04205 (KF947_04205) 893245..894474 - 1230 WP_227405531.1 tryptophan synthase subunit beta -
KF947_RS04210 (KF947_04210) 894581..895483 + 903 WP_227405532.1 LysR family transcriptional regulator -
KF947_RS04215 (KF947_04215) 895480..895740 - 261 WP_133730114.1 CopG family transcriptional regulator Antitoxin
KF947_RS04220 (KF947_04220) 895730..895993 - 264 WP_227405533.1 BrnT family toxin Toxin
KF947_RS04225 (KF947_04225) 896098..897039 - 942 WP_227405534.1 LysR family transcriptional regulator -
KF947_RS04230 (KF947_04230) 897112..898095 + 984 WP_227405535.1 aldo/keto reductase -
KF947_RS04235 (KF947_04235) 898111..898740 - 630 WP_227405536.1 SDR family oxidoreductase -
KF947_RS04240 (KF947_04240) 898833..899522 - 690 WP_133730109.1 VIT family protein -
KF947_RS04245 (KF947_04245) 899580..899840 - 261 WP_227405537.1 PQQ-dependent sugar dehydrogenase -
KF947_RS04250 (KF947_04250) 899951..900493 + 543 WP_227405538.1 adenylate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10245.57 Da        Isoelectric Point: 5.7362

>T201802 WP_227405533.1 NZ_CP074200:c895993-895730 [Halomonas sp. FeN2]
MNDFEFDEEKSAANRVKHGIDFLDAQALWNDPDLLEIQAKSNDEPRFLVVGLIGVKHWSAVITYRNERIRLISVRRSRKR
EVELYES

Download         Length: 264 bp

>T201802 NZ_CP098769:c4965331-4964414 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9904.21 Da        Isoelectric Point: 5.1632

>AT201802 WP_133730114.1 NZ_CP074200:c895740-895480 [Halomonas sp. FeN2]
MKANDFDKKFDQGCEDIVDDLELSTVRRVNQEQKRINVDFPAWVVESLDREAARIGVTRQSIIKVWLVERLKAEAADKPS
NNPLPH

Download         Length: 261 bp

>AT201802 NZ_CP098769:c4966095-4965337 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References