Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 850839..851433 Replicon chromosome
Accession NZ_CP074200
Organism Halomonas sp. FeN2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KF947_RS04005 Protein ID WP_264478740.1
Coordinates 850839..851135 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KF947_RS04010 Protein ID WP_088699118.1
Coordinates 851140..851433 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF947_RS03985 (KF947_03985) 846502..847017 - 516 WP_133730153.1 5-(carboxyamino)imidazole ribonucleotide mutase -
KF947_RS03990 (KF947_03990) 847237..847509 + 273 WP_008958942.1 XRE family transcriptional regulator -
KF947_RS03995 (KF947_03995) 847679..848872 - 1194 WP_227405498.1 chromate efflux transporter -
KF947_RS04000 (KF947_04000) 848985..850667 - 1683 WP_133730151.1 dihydroxy-acid dehydratase -
KF947_RS04005 (KF947_04005) 850839..851135 + 297 WP_264478740.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF947_RS04010 (KF947_04010) 851140..851433 + 294 WP_088699118.1 putative addiction module antidote protein Antitoxin
KF947_RS04015 (KF947_04015) 851545..855174 + 3630 WP_227405500.1 exodeoxyribonuclease V subunit gamma -
KF947_RS04020 (KF947_04020) 855183..856118 - 936 WP_227405501.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-90)

Antitoxin

Uncharacterized protein HI1420

(7-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10967.88 Da        Isoelectric Point: 10.1397

>T201801 WP_264478740.1 NZ_CP074200:850839-851135 [Halomonas sp. FeN2]
IIELIKTDVFDRWLRELRDVRARAKVEARIRRLSLGNPGDVKPVGKGVSELRIPYGPGCRIYYITKGPVIVVLLCGGDKA
TQSHDIELAKAIAAQWKE

Download         Length: 297 bp

>T201801 NZ_CP098769:c4808515-4808231 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10405.77 Da        Isoelectric Point: 4.3707

>AT201801 WP_088699118.1 NZ_CP074200:851140-851433 [Halomonas sp. FeN2]
MTVPNVTFSHYDTADYLQTEEDIAAYLDAVMEENDPALLAAALGDIARARNMSQLAKDVGMSREGLYKALSGEGNPAFST
ISKVANSLGLRLSIKPL

Download         Length: 294 bp

>AT201801 NZ_CP098769:c4808747-4808505 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References