Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 75780..76519 Replicon plasmid pJBIWA001_4
Accession NZ_CP074186
Organism Raoultella planticola strain JBIWA001

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag KGP19_RS29375 Protein ID WP_076752153.1
Coordinates 75780..76265 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag KGP19_RS29380 Protein ID WP_012540086.1
Coordinates 76253..76519 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP19_RS29330 (KGP19_29200) 70784..71260 + 477 WP_076752132.1 transglycosylase SLT domain-containing protein -
KGP19_RS29335 (KGP19_29205) 71298..71828 - 531 WP_076752134.1 antirestriction protein -
KGP19_RS29340 (KGP19_29210) 72020..72250 + 231 WP_076752135.1 hypothetical protein -
KGP19_RS29345 (KGP19_29215) 72454..73287 - 834 WP_076752137.1 N-6 DNA methylase -
KGP19_RS29350 (KGP19_29220) 73334..73564 - 231 WP_076752138.1 hypothetical protein -
KGP19_RS29355 (KGP19_29225) 73653..74000 - 348 WP_076752140.1 hypothetical protein -
KGP19_RS29360 (KGP19_29230) 74103..74375 - 273 WP_137055850.1 hypothetical protein -
KGP19_RS29365 (KGP19_29235) 75280..75399 - 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
KGP19_RS29370 75344..75496 - 153 WP_223526259.1 DUF5431 family protein -
KGP19_RS29375 (KGP19_29240) 75780..76265 - 486 WP_076752153.1 GNAT family N-acetyltransferase Toxin
KGP19_RS29380 (KGP19_29245) 76253..76519 - 267 WP_012540086.1 DUF1778 domain-containing protein Antitoxin
KGP19_RS29385 (KGP19_29250) 76820..77143 + 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
KGP19_RS29390 (KGP19_29255) 77145..77744 + 600 Protein_93 arsenical resistance protein ArsH -
KGP19_RS29400 (KGP19_29265) 78980..79090 + 111 Protein_95 arsenical resistance protein ArsH -
KGP19_RS29405 (KGP19_29270) 79099..79644 + 546 WP_047365773.1 sigma-70 family RNA polymerase sigma factor -
KGP19_RS29410 (KGP19_29275) 79720..80082 + 363 WP_013087168.1 arsenic metallochaperone ArsD family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(6')-Ib-cr / ARR-3 / dfrA27 / aadA16 / qacE / sul1 / qnrB91 / mph(A) - 1..102491 102491


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-152)

Antitoxin

(2-87)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17838.68 Da        Isoelectric Point: 10.0748

>T201799 WP_076752153.1 NZ_CP074186:c76265-75780 [Raoultella planticola]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q

Download         Length: 486 bp

>T201799 NZ_CP098769:4092649-4092867 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT201799 WP_012540086.1 NZ_CP074186:c76519-76253 [Raoultella planticola]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT201799 NZ_CP098769:4092248-4092622 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AWX8

References